tRNAs: cellular barcodes for amino acids

Rajat Banerjee; Shawn Chen; Kiley Dare; Marla Gilreath; Mette Praetorius-Ibba; Medha Raina; Noah M Reynolds; Theresa Rogers; Hervé Roy; Srujana S Yadavalli; Michael Ibba

doi:10.1016/j.febslet.2009.11.013

tRNAs: cellular barcodes for amino acids

Rajat Banerjee, Shawn Chen, Kiley Dare, Marla Gilreath, Mette Praetorius-Ibba, Medha Raina, Noah M Reynolds, Theresa Rogers, Hervé Roy, Srujana S Yadavalli, Michael Ibba

Transcription, RNA, and Gene Medicine Program

50 Citations (Scopus)

Abstract

The role of tRNA in translating the genetic code has received considerable attention over the last 50 years, and we now know in great detail how particular amino acids are specifically selected and brought to the ribosome in response to the corresponding mRNA codon. Over the same period, it has also become increasingly clear that the ribosome is not the only destination to which tRNAs deliver amino acids, with processes ranging from lipid modification to antibiotic biosynthesis all using aminoacyl-tRNAs as substrates. Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis.

Original language	English
Journal	FEBS Letters
Volume	584
Issue number	2
Pages (from-to)	387-95
Number of pages	9
ISSN	0014-5793
DOIs	https://doi.org/10.1016/j.febslet.2009.11.013
Publication status	Published - 21 Jan 2010

Keywords

Amino Acids
Genetic Code
Peptide Elongation Factor Tu
Protein Biosynthesis
RNA Editing
RNA, Transfer, Amino Acid-Specific
Transfer RNA Aminoacylation

Access to Document

10.1016/j.febslet.2009.11.013

Cite this

@article{56f7c02077374188a0f89150f060df21,

title = "tRNAs: cellular barcodes for amino acids",

abstract = "The role of tRNA in translating the genetic code has received considerable attention over the last 50 years, and we now know in great detail how particular amino acids are specifically selected and brought to the ribosome in response to the corresponding mRNA codon. Over the same period, it has also become increasingly clear that the ribosome is not the only destination to which tRNAs deliver amino acids, with processes ranging from lipid modification to antibiotic biosynthesis all using aminoacyl-tRNAs as substrates. Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis.",

keywords = "Amino Acids, Genetic Code, Peptide Elongation Factor Tu, Protein Biosynthesis, RNA Editing, RNA, Transfer, Amino Acid-Specific, Transfer RNA Aminoacylation",

author = "Rajat Banerjee and Shawn Chen and Kiley Dare and Marla Gilreath and Mette Praetorius-Ibba and Medha Raina and Reynolds, {Noah M} and Theresa Rogers and Herv{\'e} Roy and Yadavalli, {Srujana S} and Michael Ibba",

year = "2010",

month = jan,

day = "21",

doi = "10.1016/j.febslet.2009.11.013",

language = "English",

volume = "584",

pages = "387--95",

journal = "F E B S Letters",

issn = "0014-5793",

publisher = "JohnWiley & Sons Ltd",

number = "2",

}

TY - JOUR

T1 - tRNAs: cellular barcodes for amino acids

AU - Banerjee, Rajat

AU - Chen, Shawn

AU - Dare, Kiley

AU - Gilreath, Marla

AU - Praetorius-Ibba, Mette

AU - Raina, Medha

AU - Reynolds, Noah M

AU - Rogers, Theresa

AU - Roy, Hervé

AU - Yadavalli, Srujana S

AU - Ibba, Michael

PY - 2010/1/21

Y1 - 2010/1/21

N2 - The role of tRNA in translating the genetic code has received considerable attention over the last 50 years, and we now know in great detail how particular amino acids are specifically selected and brought to the ribosome in response to the corresponding mRNA codon. Over the same period, it has also become increasingly clear that the ribosome is not the only destination to which tRNAs deliver amino acids, with processes ranging from lipid modification to antibiotic biosynthesis all using aminoacyl-tRNAs as substrates. Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis.

AB - The role of tRNA in translating the genetic code has received considerable attention over the last 50 years, and we now know in great detail how particular amino acids are specifically selected and brought to the ribosome in response to the corresponding mRNA codon. Over the same period, it has also become increasingly clear that the ribosome is not the only destination to which tRNAs deliver amino acids, with processes ranging from lipid modification to antibiotic biosynthesis all using aminoacyl-tRNAs as substrates. Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis.

KW - Amino Acids

KW - Genetic Code

KW - Peptide Elongation Factor Tu

KW - Protein Biosynthesis

KW - RNA Editing

KW - RNA, Transfer, Amino Acid-Specific

KW - Transfer RNA Aminoacylation

U2 - 10.1016/j.febslet.2009.11.013

DO - 10.1016/j.febslet.2009.11.013

M3 - Journal article

C2 - 19903480

SN - 0014-5793

VL - 584

SP - 387

EP - 395

JO - F E B S Letters

JF - F E B S Letters

IS - 2

ER -

tRNAs: cellular barcodes for amino acids

Abstract

Keywords

Access to Document

Fingerprint

Cite this