TY - JOUR
T1 - Trends in incidence of borderline ovarian tumors in Denmark 1978-2006
AU - Hannibal, Charlotte Gerd
AU - Huusom, Lene Drasbek
AU - Kjaerbye-Thygesen, Anette
AU - Tabor, Ann
AU - Kjaer, Susanne K
N1 - © 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2011/4
Y1 - 2011/4
N2 - Objective. To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006. Design. Register-based cohort study. Setting. Denmark 1978-2006. Population. 5 079 women diagnosed with a borderline ovarian tumor in at least one of two nationwide registries (4 312 epithelial tumors and 767 non-epithelial/unspecified tumors). Methods. Estimation of overall incidence rates and period-, age- and histology-specific incidence rates. Age-adjustment was done using the World Standard Population. To evaluate incidence trends over time, we estimated average annual percentage change and 95% confidence intervals (CI) using log-linear Poisson models. Main Outcome Measures. Age-standardized and age-specific incidence rates and average annual percentage change. Results. The incidence of epithelial borderline ovarian tumors increased from 2.6 to 5.5 per 100 000 women-years between 1978 and 2006, with an average annual percentage change of 2.6% (95% CI: 2.2-3.0). The median age at diagnosis was 52 years. Women 40 years or older had a higher average annual percentage change than women younger than 40 years. Most tumors were mucinous (49.9%) and serous tumors (44.4%). Women with mucinous tumors were younger at diagnosis (50 years) compared with women with serous tumors (53 years). Women with serous tumors had a higher average annual percentage incidence change than women with mucinous tumors. Conclusions. The incidence rate of borderline ovarian tumors increased significantly in Denmark in 1978-2006. In line with results for ovarian cancer, Denmark had a higher incidence rate of borderline ovarian tumors compared with the other Nordic countries in 1978-2006.
AB - Objective. To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006. Design. Register-based cohort study. Setting. Denmark 1978-2006. Population. 5 079 women diagnosed with a borderline ovarian tumor in at least one of two nationwide registries (4 312 epithelial tumors and 767 non-epithelial/unspecified tumors). Methods. Estimation of overall incidence rates and period-, age- and histology-specific incidence rates. Age-adjustment was done using the World Standard Population. To evaluate incidence trends over time, we estimated average annual percentage change and 95% confidence intervals (CI) using log-linear Poisson models. Main Outcome Measures. Age-standardized and age-specific incidence rates and average annual percentage change. Results. The incidence of epithelial borderline ovarian tumors increased from 2.6 to 5.5 per 100 000 women-years between 1978 and 2006, with an average annual percentage change of 2.6% (95% CI: 2.2-3.0). The median age at diagnosis was 52 years. Women 40 years or older had a higher average annual percentage change than women younger than 40 years. Most tumors were mucinous (49.9%) and serous tumors (44.4%). Women with mucinous tumors were younger at diagnosis (50 years) compared with women with serous tumors (53 years). Women with serous tumors had a higher average annual percentage incidence change than women with mucinous tumors. Conclusions. The incidence rate of borderline ovarian tumors increased significantly in Denmark in 1978-2006. In line with results for ovarian cancer, Denmark had a higher incidence rate of borderline ovarian tumors compared with the other Nordic countries in 1978-2006.
U2 - 10.1111/j.1600-0412.2010.01060.x
DO - 10.1111/j.1600-0412.2010.01060.x
M3 - Journal article
SN - 0001-6349
VL - 90
SP - 305
EP - 312
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 4
ER -
