Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

Z Vegh; J Burisch; N. Pedersen; I Kaimakliotis; D Duricova; M Bortlik; K Kofod Vinding; S Avnstrøm; J. Olsen; K R Nielsen; K H Katsanos; E V Tsianos; L Lakatos; D Schwartz; S Odes; R D'Incà; M Beltrami; G Kiudelis; L Kupcinskap; A Jucov; S Turcan; L F Barros; F Magro; D Lazar; A Goldis; L de Castro; V Hernandez; O Niewiadomski; S Bell; E Langholz; P Munkholm; P L Lakatos; EpiCom Group

doi:10.1093/ecco-jcc/jjv099

Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

Z Vegh, J Burisch, N. Pedersen, I Kaimakliotis, D Duricova, M Bortlik, K Kofod Vinding, S Avnstrøm, J. Olsen, K R Nielsen, K H Katsanos, E V Tsianos, L Lakatos, D Schwartz, S Odes, R D'Incà, M Beltrami, G Kiudelis, L Kupcinskap, A JucovS Turcan, L F Barros, F Magro, D Lazar, A Goldis, L de Castro, V Hernandez, O Niewiadomski, S Bell, E Langholz, P Munkholm, P L Lakatos, EpiCom Group

Department of Clinical Medicine

26 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.

METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].

RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].

CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.

Original language	English
Journal	Journal of Crohn's & colitis
Volume	9
Issue number	9
Pages (from-to)	747-53
Number of pages	7
ISSN	1873-9946
DOIs	https://doi.org/10.1093/ecco-jcc/jjv099
Publication status	Published - 1 Sept 2015

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Vegh, Z., Burisch, J., Pedersen, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Vinding, K. K., Avnstrøm, S., Olsen, J., Nielsen, K. R., Katsanos, K. H., Tsianos, E. V., Lakatos, L., Schwartz, D., Odes, S., D'Incà, R., Beltrami, M., Kiudelis, G., Kupcinskap, L., ... EpiCom Group (2015). Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort. Journal of Crohn's & colitis, 9(9), 747-53. https://doi.org/10.1093/ecco-jcc/jjv099

Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort. / Vegh, Z; Burisch, J; Pedersen, N. et al.
In: Journal of Crohn's & colitis, Vol. 9, No. 9, 01.09.2015, p. 747-53.

Research output: Contribution to journal › Journal article › Research › peer-review

Vegh, Z, Burisch, J, Pedersen, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Vinding, KK, Avnstrøm, S, Olsen, J, Nielsen, KR, Katsanos, KH, Tsianos, EV, Lakatos, L, Schwartz, D, Odes, S, D'Incà, R, Beltrami, M, Kiudelis, G, Kupcinskap, L, Jucov, A, Turcan, S, Barros, LF, Magro, F, Lazar, D, Goldis, A, de Castro, L, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E, Munkholm, P, Lakatos, PL & EpiCom Group 2015, 'Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort', Journal of Crohn's & colitis, vol. 9, no. 9, pp. 747-53. https://doi.org/10.1093/ecco-jcc/jjv099

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title = "Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort",

abstract = "BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.",

author = "Z Vegh and J Burisch and N. Pedersen and I Kaimakliotis and D Duricova and M Bortlik and Vinding, {K Kofod} and S Avnstr{\o}m and J. Olsen and Nielsen, {K R} and Katsanos, {K H} and Tsianos, {E V} and L Lakatos and D Schwartz and S Odes and R D'Inc{\`a} and M Beltrami and G Kiudelis and L Kupcinskap and A Jucov and S Turcan and Barros, {L F} and F Magro and D Lazar and A Goldis and {de Castro}, L and V Hernandez and O Niewiadomski and S Bell and E Langholz and P Munkholm and Lakatos, {P L} and {EpiCom Group}",

note = "Copyright {\textcopyright} 2015 European Crohn{\textquoteright}s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].",

year = "2015",

month = sep,

day = "1",

doi = "10.1093/ecco-jcc/jjv099",

language = "English",

volume = "9",

pages = "747--53",

journal = "Journal of Crohn's & colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "9",

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TY - JOUR

T1 - Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

AU - Vegh, Z

AU - Burisch, J

AU - Pedersen, N.

AU - Kaimakliotis, I

AU - Duricova, D

AU - Bortlik, M

AU - Vinding, K Kofod

AU - Avnstrøm, S

AU - Olsen, J.

AU - Nielsen, K R

AU - Katsanos, K H

AU - Tsianos, E V

AU - Lakatos, L

AU - Schwartz, D

AU - Odes, S

AU - D'Incà, R

AU - Beltrami, M

AU - Kiudelis, G

AU - Kupcinskap, L

AU - Jucov, A

AU - Turcan, S

AU - Barros, L F

AU - Magro, F

AU - Lazar, D

AU - Goldis, A

AU - de Castro, L

AU - Hernandez, V

AU - Niewiadomski, O

AU - Bell, S

AU - Langholz, E

AU - Munkholm, P

AU - Lakatos, P L

AU - EpiCom Group

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.

AB - BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.

U2 - 10.1093/ecco-jcc/jjv099

DO - 10.1093/ecco-jcc/jjv099

M3 - Journal article

C2 - 26055976

SN - 1873-9946

VL - 9

SP - 747

EP - 753

JO - Journal of Crohn's & colitis

JF - Journal of Crohn's & colitis

IS - 9

ER -

Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

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