Transient elastography for liver fibrosis diagnosis

Ellen Sloth Andersen; Peer Brehm Christensen; Nina Weis; Nina Weis

doi:http://dx.doi.org/10.1016/j.ejim.2008.09.020

Transient elastography for liver fibrosis diagnosis

Ellen Sloth Andersen, Peer Brehm Christensen, Nina Weis, Nina Weis

Department of Clinical Medicine

30 Citations (Scopus)

Abstract

Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems. Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate fibrosis. Most of the studies have been conducted on patients with chronic hepatitis but a few studies have also covered fibrosis and cirrhosis due to other etiologies, and they also demonstrate the high sensitivity and specificity. Transient elastography for assessment of fibrosis may turn out to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases.

Original language	English
Journal	European Journal of Internal Medicine
Volume	20
Issue number	4
Pages (from-to)	339-42
Number of pages	3
ISSN	0953-6205
DOIs	https://doi.org/10.1016/j.ejim.2008.09.020
Publication status	Published - 2008

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title = "Transient elastography for liver fibrosis diagnosis",

abstract = "Liver biopsy is considered the {"}golden standard{"} for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems. Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate fibrosis. Most of the studies have been conducted on patients with chronic hepatitis but a few studies have also covered fibrosis and cirrhosis due to other etiologies, and they also demonstrate the high sensitivity and specificity. Transient elastography for assessment of fibrosis may turn out to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases.",

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T1 - Transient elastography for liver fibrosis diagnosis

AU - Andersen, Ellen Sloth

AU - Christensen, Peer Brehm

AU - Weis, Nina

PY - 2008

Y1 - 2008

N2 - Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems. Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate fibrosis. Most of the studies have been conducted on patients with chronic hepatitis but a few studies have also covered fibrosis and cirrhosis due to other etiologies, and they also demonstrate the high sensitivity and specificity. Transient elastography for assessment of fibrosis may turn out to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases.

AB - Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems. Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate fibrosis. Most of the studies have been conducted on patients with chronic hepatitis but a few studies have also covered fibrosis and cirrhosis due to other etiologies, and they also demonstrate the high sensitivity and specificity. Transient elastography for assessment of fibrosis may turn out to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases.

U2 - http://dx.doi.org/10.1016/j.ejim.2008.09.020

DO - http://dx.doi.org/10.1016/j.ejim.2008.09.020

M3 - Journal article

SN - 0953-6205

VL - 20

SP - 339

EP - 342

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - 4

ER -

Transient elastography for liver fibrosis diagnosis

Abstract

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