Abstract
Background: A recently developed transdermal fentanyl solution was hypothesized to be effective for noninvasive postoperative analgesia in rats. Materials and Methods: Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. Results: Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. Conclusion: The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.
| Original language | English |
|---|---|
| Journal | In Vivo |
| Volume | 32 |
| Issue number | 4 |
| Pages (from-to) | 713-719 |
| Number of pages | 7 |
| ISSN | 0258-851X |
| DOIs | |
| Publication status | Published - 1 Jul 2018 |
Keywords
- Analgesia
- Fentanyl
- Laboratory rats
- Pain
- Transdermal