Transcriptional regulation of nitrogen-associated metabolism and growth

Allison Gaudinier; Joel Rodriguez-Medina; Lifang Zhang; Andrew Olson; Christophe Liseron-Monfils; Anne Maarit Bågman; Jessica Foret; Shane Abbitt; Michelle Tang; Baohua Li; Daniel E. Runcie; Daniel J. Kliebenstein; Bo Shen; Mary J. Frank; Doreen Ware; Siobhan M. Brady

doi:10.1038/s41586-018-0656-3

Transcriptional regulation of nitrogen-associated metabolism and growth

Allison Gaudinier, Joel Rodriguez-Medina, Lifang Zhang, Andrew Olson, Christophe Liseron-Monfils, Anne Maarit Bågman, Jessica Foret, Shane Abbitt, Michelle Tang, Baohua Li, Daniel E. Runcie, Daniel J. Kliebenstein, Bo Shen, Mary J. Frank, Doreen Ware, Siobhan M. Brady^*

^*Corresponding author for this work

Section for Molecular Plant Biology

59 Citations (Scopus)

Abstract

Nitrogen is an essential macronutrient for plant growth and basic metabolic processes. The application of nitrogen-containing fertilizer increases yield, which has been a substantial factor in the green revolution¹. Ecologically, however, excessive application of fertilizer has disastrous effects such as eutrophication². A better understanding of how plants regulate nitrogen metabolism is critical to increase plant yield and reduce fertilizer overuse. Here we present a transcriptional regulatory network and twenty-one transcription factors that regulate the architecture of root and shoot systems in response to changes in nitrogen availability. Genetic perturbation of a subset of these transcription factors revealed coordinate transcriptional regulation of enzymes involved in nitrogen metabolism. Transcriptional regulators in the network are transcriptionally modified by feedback via genetic perturbation of nitrogen metabolism. The network, genes and gene-regulatory modules identified here will prove critical to increasing agricultural productivity.

Original language	English
Journal	Nature
Volume	563
Issue number	7730
Pages (from-to)	259-264
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-018-0656-3
Publication status	Published - 8 Nov 2018

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Gaudinier, A., Rodriguez-Medina, J., Zhang, L., Olson, A., Liseron-Monfils, C., Bågman, A. M., Foret, J., Abbitt, S., Tang, M., Li, B., Runcie, D. E., Kliebenstein, D. J., Shen, B., Frank, M. J., Ware, D., & Brady, S. M. (2018). Transcriptional regulation of nitrogen-associated metabolism and growth. Nature, 563(7730), 259-264. https://doi.org/10.1038/s41586-018-0656-3

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title = "Transcriptional regulation of nitrogen-associated metabolism and growth",

abstract = "Nitrogen is an essential macronutrient for plant growth and basic metabolic processes. The application of nitrogen-containing fertilizer increases yield, which has been a substantial factor in the green revolution1. Ecologically, however, excessive application of fertilizer has disastrous effects such as eutrophication2. A better understanding of how plants regulate nitrogen metabolism is critical to increase plant yield and reduce fertilizer overuse. Here we present a transcriptional regulatory network and twenty-one transcription factors that regulate the architecture of root and shoot systems in response to changes in nitrogen availability. Genetic perturbation of a subset of these transcription factors revealed coordinate transcriptional regulation of enzymes involved in nitrogen metabolism. Transcriptional regulators in the network are transcriptionally modified by feedback via genetic perturbation of nitrogen metabolism. The network, genes and gene-regulatory modules identified here will prove critical to increasing agricultural productivity.",

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AU - Gaudinier, Allison

AU - Rodriguez-Medina, Joel

AU - Zhang, Lifang

AU - Olson, Andrew

AU - Liseron-Monfils, Christophe

AU - Bågman, Anne Maarit

AU - Foret, Jessica

AU - Abbitt, Shane

AU - Tang, Michelle

AU - Li, Baohua

AU - Runcie, Daniel E.

AU - Kliebenstein, Daniel J.

AU - Shen, Bo

AU - Frank, Mary J.

AU - Ware, Doreen

AU - Brady, Siobhan M.

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N2 - Nitrogen is an essential macronutrient for plant growth and basic metabolic processes. The application of nitrogen-containing fertilizer increases yield, which has been a substantial factor in the green revolution1. Ecologically, however, excessive application of fertilizer has disastrous effects such as eutrophication2. A better understanding of how plants regulate nitrogen metabolism is critical to increase plant yield and reduce fertilizer overuse. Here we present a transcriptional regulatory network and twenty-one transcription factors that regulate the architecture of root and shoot systems in response to changes in nitrogen availability. Genetic perturbation of a subset of these transcription factors revealed coordinate transcriptional regulation of enzymes involved in nitrogen metabolism. Transcriptional regulators in the network are transcriptionally modified by feedback via genetic perturbation of nitrogen metabolism. The network, genes and gene-regulatory modules identified here will prove critical to increasing agricultural productivity.

AB - Nitrogen is an essential macronutrient for plant growth and basic metabolic processes. The application of nitrogen-containing fertilizer increases yield, which has been a substantial factor in the green revolution1. Ecologically, however, excessive application of fertilizer has disastrous effects such as eutrophication2. A better understanding of how plants regulate nitrogen metabolism is critical to increase plant yield and reduce fertilizer overuse. Here we present a transcriptional regulatory network and twenty-one transcription factors that regulate the architecture of root and shoot systems in response to changes in nitrogen availability. Genetic perturbation of a subset of these transcription factors revealed coordinate transcriptional regulation of enzymes involved in nitrogen metabolism. Transcriptional regulators in the network are transcriptionally modified by feedback via genetic perturbation of nitrogen metabolism. The network, genes and gene-regulatory modules identified here will prove critical to increasing agricultural productivity.

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SN - 0028-0836

VL - 563

SP - 259

EP - 264

JO - Nature

JF - Nature

IS - 7730

ER -

Transcriptional regulation of nitrogen-associated metabolism and growth

Abstract

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