Abstract
The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg-1) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety-Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP, and catecholamines by the Fick principle in 12 volunteers before and after LPS infusion. The cerebrovascular release of ET-1 was enhanced, whereas the transcerebral net exchange of CGRP and catecholamines was unaffected. Our findings thus point towards locally produced ET-1 within the cerebrovasculature as a contributor to cerebral vasoconstriction after LPS infusion.
| Original language | English |
|---|---|
| Journal | Canadian Journal of Physiology and Pharmacology |
| Volume | 96 |
| Issue number | 3 |
| Pages (from-to) | 313-316 |
| Number of pages | 4 |
| ISSN | 0008-4212 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- Adult
- Brain/blood supply
- Calcitonin Gene-Related Peptide/metabolism
- Catecholamines/metabolism
- Endothelin-1/metabolism
- Healthy Volunteers
- Humans
- Lipopolysaccharides/pharmacology
- Male
- Systemic Inflammatory Response Syndrome/metabolism
- Vasoconstriction/drug effects