Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study

Marianne Uhre Jakobsen; Anders Gorst-Rasmussen; Helle H Eriksen; Jakob Stegger; Albert M Joensen; Anne Tjønneland; Jørn Dyerberg; Erik B Schmidt; Kim Overvad

doi:10.1371/journal.pone.0202363

Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study

Marianne Uhre Jakobsen^*, Anders Gorst-Rasmussen, Helle H Eriksen, Jakob Stegger, Albert M Joensen, Anne Tjønneland, Jørn Dyerberg, Erik B Schmidt, Kim Overvad

^*Corresponding author for this work

Obesity Research

3 Citations (Scopus)

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Abstract

Background: The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism.

Objective: We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t.

Methods: A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography.

Results: Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12–2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23–2.51; P-trend = 0.002). No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17–1.86; P-trend = 0.003). Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men.

Conclusions: Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.

Original language	English
Article number	e0202363
Journal	P L o S One
Volume	13
Issue number	8
Number of pages	14
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0202363
Publication status	Published - 2018

Keywords

Faculty of Science
Myocardial infarction
Adipose tissue
Fatty acids
Isomers
Diet
Diabetes mellitus
Physical activity
Hypertension

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0202363Licence: CC BY

Jakobsen et al_PLoS ONE_2018_Vol 13(8)_e0202363Final published version, 1.17 MBLicence: CC BY

Cite this

@article{8e8a7ec35b554528a385052bf52f3bcc,

title = "Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study",

abstract = "Background: The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism. Objective: We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t. Methods: A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography. Results: Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12–2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23–2.51; P-trend = 0.002). No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17–1.86; P-trend = 0.003). Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men. Conclusions: Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.",

keywords = "Faculty of Science, Myocardial infarction, Adipose tissue, Fatty acids, Isomers, Diet, Diabetes mellitus, Physical activity, Hypertension",

author = "Jakobsen, {Marianne Uhre} and Anders Gorst-Rasmussen and Eriksen, {Helle H} and Jakob Stegger and Joensen, {Albert M} and Anne Tj{\o}nneland and J{\o}rn Dyerberg and Schmidt, {Erik B} and Kim Overvad",

note = "CURIS 2018 NEXS 306",

year = "2018",

doi = "10.1371/journal.pone.0202363",

language = "English",

volume = "13",

journal = "P L o S One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

TY - JOUR

T1 - Trans fatty acids in adipose tissue and risk of myocardial infarction

T2 - A case-cohort study

AU - Jakobsen, Marianne Uhre

AU - Gorst-Rasmussen, Anders

AU - Eriksen, Helle H

AU - Stegger, Jakob

AU - Joensen, Albert M

AU - Tjønneland, Anne

AU - Dyerberg, Jørn

AU - Schmidt, Erik B

AU - Overvad, Kim

N1 - CURIS 2018 NEXS 306

PY - 2018

Y1 - 2018

N2 - Background: The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism. Objective: We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t. Methods: A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography. Results: Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12–2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23–2.51; P-trend = 0.002). No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17–1.86; P-trend = 0.003). Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men. Conclusions: Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.

AB - Background: The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism. Objective: We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t. Methods: A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography. Results: Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12–2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23–2.51; P-trend = 0.002). No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17–1.86; P-trend = 0.003). Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men. Conclusions: Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.

KW - Faculty of Science

KW - Myocardial infarction

KW - Adipose tissue

KW - Fatty acids

KW - Isomers

KW - Diet

KW - Diabetes mellitus

KW - Physical activity

KW - Hypertension

U2 - 10.1371/journal.pone.0202363

DO - 10.1371/journal.pone.0202363

M3 - Journal article

C2 - 30133507

AN - SCOPUS:85052120658

SN - 1932-6203

VL - 13

JO - P L o S One

JF - P L o S One

IS - 8

M1 - e0202363

ER -

Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study

Abstract

Keywords

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