Tramadol poisoning with hyperamylasemia

Alaa Abdul-Hussein Hmood El-Hussuna; Regnar Bøge Arnesen; Jacob Rosenberg

doi:http://dx.doi.org/10.1136/bcr.03.2010.2821

Tramadol poisoning with hyperamylasemia

Alaa Abdul-Hussein Hmood El-Hussuna, Regnar Bøge Arnesen, Jacob Rosenberg

4 Citations (Scopus)

Abstract

The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.

Original language	English
Journal	B M J Case Reports
ISSN	1757-790X
DOIs	https://doi.org/10.1136/bcr.03.2010.2821
Publication status	Published - 10 Aug 2010

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title = "Tramadol poisoning with hyperamylasemia",

abstract = "The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.",

author = "El-Hussuna, {Alaa Abdul-Hussein Hmood} and Arnesen, {Regnar B{\o}ge} and Jacob Rosenberg",

year = "2010",

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doi = "http://dx.doi.org/10.1136/bcr.03.2010.2821",

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TY - JOUR

T1 - Tramadol poisoning with hyperamylasemia

AU - El-Hussuna, Alaa Abdul-Hussein Hmood

AU - Arnesen, Regnar Bøge

AU - Rosenberg, Jacob

PY - 2010/8/10

Y1 - 2010/8/10

N2 - The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.

AB - The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.

U2 - http://dx.doi.org/10.1136/bcr.03.2010.2821

DO - http://dx.doi.org/10.1136/bcr.03.2010.2821

M3 - Journal article

SN - 1757-790X

JO - BMJ Case Reports

JF - BMJ Case Reports

ER -

Tramadol poisoning with hyperamylasemia

Abstract

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