T(peak)T(end) interval in long QT syndrome

Jørgen Kim Kanters; Christian Haarmark; Esben Vedel-Larsen; Mads P Andersen; Claus Graff; Johannes J Struijk; Poul Erik Bloch Thomsen; Michael Christiansen; Henrik K Jensen; Egon Toft

doi:10.1016/j.jelectrocard.2008.07.024

T(peak)T(end) interval in long QT syndrome

Jørgen Kim Kanters, Christian Haarmark, Esben Vedel-Larsen, Mads P Andersen, Claus Graff, Johannes J Struijk, Poul Erik Bloch Thomsen, Michael Christiansen, Henrik K Jensen, Egon Toft

46 Citations (Scopus)

Abstract

BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.

Original language	English
Journal	Journal of Electrocardiology
Volume	41
Issue number	6
Pages (from-to)	603-8
Number of pages	5
ISSN	0022-0736
DOIs	https://doi.org/10.1016/j.jelectrocard.2008.07.024
Publication status	Published - 2008

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10.1016/j.jelectrocard.2008.07.024

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@article{6b867c6061a811df928f000ea68e967b,

title = "T(peak)T(end) interval in long QT syndrome",

abstract = "BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.",

author = "Kanters, {J{\o}rgen Kim} and Christian Haarmark and Esben Vedel-Larsen and Andersen, {Mads P} and Claus Graff and Struijk, {Johannes J} and Thomsen, {Poul Erik Bloch} and Michael Christiansen and Jensen, {Henrik K} and Egon Toft",

note = "Keywords: Adult; Comorbidity; Denmark; Diagnosis, Computer-Assisted; Electrocardiography; Female; Humans; Incidence; Long QT Syndrome; Male; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Syncope",

year = "2008",

doi = "10.1016/j.jelectrocard.2008.07.024",

language = "English",

volume = "41",

pages = "603--8",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Churchill Livingstone",

number = "6",

}

TY - JOUR

T1 - T(peak)T(end) interval in long QT syndrome

AU - Kanters, Jørgen Kim

AU - Haarmark, Christian

AU - Vedel-Larsen, Esben

AU - Andersen, Mads P

AU - Graff, Claus

AU - Struijk, Johannes J

AU - Thomsen, Poul Erik Bloch

AU - Christiansen, Michael

AU - Jensen, Henrik K

AU - Toft, Egon

N1 - Keywords: Adult; Comorbidity; Denmark; Diagnosis, Computer-Assisted; Electrocardiography; Female; Humans; Incidence; Long QT Syndrome; Male; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Syncope

PY - 2008

Y1 - 2008

N2 - BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.

AB - BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.

U2 - 10.1016/j.jelectrocard.2008.07.024

DO - 10.1016/j.jelectrocard.2008.07.024

M3 - Journal article

C2 - 18822425

SN - 0022-0736

VL - 41

SP - 603

EP - 608

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 6

ER -

T(peak)T(end) interval in long QT syndrome

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