TY - JOUR
T1 - Time-related survival effects of two gluconasturtiin hydrolysis products on the terrestrial isopod Porcellio scaber
AU - van Ommen Kloeke, A E Elaine
AU - Jager, Tjalling
AU - van Gestel, Cornelis A M
AU - Ellers, Jacintha
AU - Pomeren, Marinda van
AU - Krommenhoek, Thibault
AU - Styrishave, Bjarne
AU - Hansen, Martin
AU - Roelofs, Dick
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/11
Y1 - 2012/11
N2 - Glucosinolates are compounds produced by commercial crops which can hydrolyse in a range of natural toxins that may exert detrimental effects on beneficial soil organisms. This study examined the effects of 2-phenylethyl isothiocyanate and 3-phenylpropionitrile on the survival and growth of the woodlouse Porcellio scaber exposed for 28d. 2-Phenylethyl isothiocyanate dissipated from the soil with half-lives ranging from 19 to 96h. Exposure through soil showed toxic effects only on survival. The LC50s after 28d were significantly different at 65.3mgkg(-1) for 2-phenylethyl isothiocyanate and 155mgkg(-1) for 3-phenylpropionitrile. A toxicokinetic-toxicodynamic (TKTD) approach, however, revealed that both compounds in fact have very similar effect patterns. The TKTD model was better suited to interpret the survival data than descriptive dose-response analysis (LC(x)), accounting for the fast dissipation of the compounds in the soil. Found effects were within environmentally relevant concentrations. Care should therefore be taken before allowing these natural toxins to enter soil ecosystems in large quantities.
AB - Glucosinolates are compounds produced by commercial crops which can hydrolyse in a range of natural toxins that may exert detrimental effects on beneficial soil organisms. This study examined the effects of 2-phenylethyl isothiocyanate and 3-phenylpropionitrile on the survival and growth of the woodlouse Porcellio scaber exposed for 28d. 2-Phenylethyl isothiocyanate dissipated from the soil with half-lives ranging from 19 to 96h. Exposure through soil showed toxic effects only on survival. The LC50s after 28d were significantly different at 65.3mgkg(-1) for 2-phenylethyl isothiocyanate and 155mgkg(-1) for 3-phenylpropionitrile. A toxicokinetic-toxicodynamic (TKTD) approach, however, revealed that both compounds in fact have very similar effect patterns. The TKTD model was better suited to interpret the survival data than descriptive dose-response analysis (LC(x)), accounting for the fast dissipation of the compounds in the soil. Found effects were within environmentally relevant concentrations. Care should therefore be taken before allowing these natural toxins to enter soil ecosystems in large quantities.
U2 - 10.1016/j.chemosphere.2012.05.074
DO - 10.1016/j.chemosphere.2012.05.074
M3 - Journal article
C2 - 22698371
SN - 0045-6535
VL - 89
SP - 1084
EP - 1090
JO - Chemosphere
JF - Chemosphere
IS - 9
ER -