Thymic size in preterm neonates: a sonographic study

Dorthe Lisbeth Jeppesen; H Hasselbalch; Susanne Dam Poulsen; TU Sorensen; AK Ersboll; NH Valerius; C Heilmann

doi:http://dx.doi.org/10.1111/j.1651-2227.2003.tb02539.x

Thymic size in preterm neonates: a sonographic study

Dorthe Lisbeth Jeppesen, H Hasselbalch, Susanne Dam Poulsen, TU Sorensen, AK Ersboll, NH Valerius, C Heilmann

Department of Clinical Medicine

30 Citations (Scopus)

Abstract

AIM: To assess the variation in size of the thymus in vivo in preterm neonates and to identify relations between thymic size and gestational age (GA), birthweight, occurrence of postnatal infections and maternal alcohol and tobacco intake during pregnancy. METHODS: Eighty preterm neonates with a GA between 24 and 36 wk, and a birthweight between 490 and 4110 g were examined between days 0 and 19 after birth. The thymic size was assessed by sonography as a volume estimate, the so-called thymic index (Ti). The median Ti was 5.2 (1.2-17.9). Ti was positively correlated with birthweight and GA and negatively correlated with occurrence of postnatal infection (p < 0.01, p = 0.03, p = 0.05, R2 = 0.68). A correlation between thymic size and maternal alcohol and tobacco intake was not demonstrated. CONCLUSION: It is possible to assess the size of the thymus by sonography in very low-birthweight and preterm neonates. A normal range for Ti in preterm neonates has been established. The sonographic method is a safe and effective technique for measuring the size of the thymus in preterm infants.

Original language	English
Journal	Acta Paediatrica
Volume	92
Issue number	7
Pages (from-to)	817-22
ISSN	0803-5253
DOIs	https://doi.org/10.1111/j.1651-2227.2003.tb02539.x
Publication status	Published - 2003

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title = "Thymic size in preterm neonates: a sonographic study",

abstract = "AIM: To assess the variation in size of the thymus in vivo in preterm neonates and to identify relations between thymic size and gestational age (GA), birthweight, occurrence of postnatal infections and maternal alcohol and tobacco intake during pregnancy. METHODS: Eighty preterm neonates with a GA between 24 and 36 wk, and a birthweight between 490 and 4110 g were examined between days 0 and 19 after birth. The thymic size was assessed by sonography as a volume estimate, the so-called thymic index (Ti). The median Ti was 5.2 (1.2-17.9). Ti was positively correlated with birthweight and GA and negatively correlated with occurrence of postnatal infection (p < 0.01, p = 0.03, p = 0.05, R2 = 0.68). A correlation between thymic size and maternal alcohol and tobacco intake was not demonstrated. CONCLUSION: It is possible to assess the size of the thymus by sonography in very low-birthweight and preterm neonates. A normal range for Ti in preterm neonates has been established. The sonographic method is a safe and effective technique for measuring the size of the thymus in preterm infants.",

author = "Jeppesen, {Dorthe Lisbeth} and H Hasselbalch and Poulsen, {Susanne Dam} and TU Sorensen and AK Ersboll and NH Valerius and C Heilmann",

year = "2003",

doi = "http://dx.doi.org/10.1111/j.1651-2227.2003.tb02539.x",

language = "English",

volume = "92",

pages = "817--22",

journal = "Acta Paediatrica, International Journal of Paediatrics, Supplement",

issn = "0803-5253",

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TY - JOUR

T1 - Thymic size in preterm neonates: a sonographic study

AU - Jeppesen, Dorthe Lisbeth

AU - Hasselbalch, H

AU - Poulsen, Susanne Dam

AU - Sorensen, TU

AU - Ersboll, AK

AU - Valerius, NH

AU - Heilmann, C

PY - 2003

Y1 - 2003

N2 - AIM: To assess the variation in size of the thymus in vivo in preterm neonates and to identify relations between thymic size and gestational age (GA), birthweight, occurrence of postnatal infections and maternal alcohol and tobacco intake during pregnancy. METHODS: Eighty preterm neonates with a GA between 24 and 36 wk, and a birthweight between 490 and 4110 g were examined between days 0 and 19 after birth. The thymic size was assessed by sonography as a volume estimate, the so-called thymic index (Ti). The median Ti was 5.2 (1.2-17.9). Ti was positively correlated with birthweight and GA and negatively correlated with occurrence of postnatal infection (p < 0.01, p = 0.03, p = 0.05, R2 = 0.68). A correlation between thymic size and maternal alcohol and tobacco intake was not demonstrated. CONCLUSION: It is possible to assess the size of the thymus by sonography in very low-birthweight and preterm neonates. A normal range for Ti in preterm neonates has been established. The sonographic method is a safe and effective technique for measuring the size of the thymus in preterm infants.

AB - AIM: To assess the variation in size of the thymus in vivo in preterm neonates and to identify relations between thymic size and gestational age (GA), birthweight, occurrence of postnatal infections and maternal alcohol and tobacco intake during pregnancy. METHODS: Eighty preterm neonates with a GA between 24 and 36 wk, and a birthweight between 490 and 4110 g were examined between days 0 and 19 after birth. The thymic size was assessed by sonography as a volume estimate, the so-called thymic index (Ti). The median Ti was 5.2 (1.2-17.9). Ti was positively correlated with birthweight and GA and negatively correlated with occurrence of postnatal infection (p < 0.01, p = 0.03, p = 0.05, R2 = 0.68). A correlation between thymic size and maternal alcohol and tobacco intake was not demonstrated. CONCLUSION: It is possible to assess the size of the thymus by sonography in very low-birthweight and preterm neonates. A normal range for Ti in preterm neonates has been established. The sonographic method is a safe and effective technique for measuring the size of the thymus in preterm infants.

U2 - http://dx.doi.org/10.1111/j.1651-2227.2003.tb02539.x

DO - http://dx.doi.org/10.1111/j.1651-2227.2003.tb02539.x

M3 - Journal article

SN - 0803-5253

VL - 92

SP - 817

EP - 822

JO - Acta Paediatrica, International Journal of Paediatrics, Supplement

JF - Acta Paediatrica, International Journal of Paediatrics, Supplement

IS - 7

ER -

Thymic size in preterm neonates: a sonographic study

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