TY - JOUR
T1 - Threshold electrical stimulation (TES) in ambulant children with CP: a randomized double-blind placebo-controlled clinical trial
AU - Dali, Christine í
AU - Hansen, Flemming Juul
AU - Pedersen, Søren Anker
AU - Skov, Liselotte
AU - Hilden, Jørgen
AU - Bjørnskov, Inge
AU - Strandberg, Charlotte
AU - Christensen, Jette
AU - Haugsted, Ulla
AU - Herbst, Grethe
AU - Lyskjaer, Ulla
N1 - Keywords: Adolescent; Cerebral Palsy; Child; Child, Preschool; Double-Blind Method; Electric Stimulation Therapy; Female; Humans; Male; Motor Skills Disorders; Muscle, Skeletal; Placebos; Severity of Illness Index; Treatment Outcome
PY - 2002
Y1 - 2002
N2 - A randomized double-blind placebo-controlled clinical trial was carried out to determine whether a group of stable children with cerebral palsy (36 males, 21 females; mean age 10 years 11 months, range 5 to 18 years) would improve their motor skills after 12 months of threshold electrical stimulation (TES). Two thirds received active and one third received inactive stimulators. For the primary outcome we constructed a set of plausible motor function tests and studied the change in summary indices of the performance measurements. Tests were videotaped and assessed blindly to record qualitative changes that might not be reflected in performance measurements. We also judged range of motion, degree of spasticity, and muscle growth measured by CT. Fifty seven of 82 outpatients who were able to walk at least with a walker, completed all 12 months of treatment (hemiplegia n=25, diplegia n=32). There was no significant difference between active and placebo treatment in any of the tested groups, nor combined. Visual and subjective assessments favoured TES (ns), whereas objective indices showed the opposite trend. We conclude that TES in these patients did not have any significant clinical effect during the test period.
AB - A randomized double-blind placebo-controlled clinical trial was carried out to determine whether a group of stable children with cerebral palsy (36 males, 21 females; mean age 10 years 11 months, range 5 to 18 years) would improve their motor skills after 12 months of threshold electrical stimulation (TES). Two thirds received active and one third received inactive stimulators. For the primary outcome we constructed a set of plausible motor function tests and studied the change in summary indices of the performance measurements. Tests were videotaped and assessed blindly to record qualitative changes that might not be reflected in performance measurements. We also judged range of motion, degree of spasticity, and muscle growth measured by CT. Fifty seven of 82 outpatients who were able to walk at least with a walker, completed all 12 months of treatment (hemiplegia n=25, diplegia n=32). There was no significant difference between active and placebo treatment in any of the tested groups, nor combined. Visual and subjective assessments favoured TES (ns), whereas objective indices showed the opposite trend. We conclude that TES in these patients did not have any significant clinical effect during the test period.
M3 - Journal article
C2 - 12088304
SN - 0419-0238
VL - 44
SP - 364
EP - 369
JO - Developmental medicine and child neurology. Supplement
JF - Developmental medicine and child neurology. Supplement
IS - 6
ER -