Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men

Anne Sofie Gram; Else-Marie Bladbjerg; Jane Skov; Thorkil Ploug; Anders Sjödin; Mads Rosenkilde Larsen; Daniel Elenius Madsen; Bente Merete Stallknecht

doi:10.1007/s00421-015-3106-z

Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men

Anne Sofie Gram, Else-Marie Bladbjerg, Jane Skov, Thorkil Ploug, Anders Sjödin, Mads Rosenkilde Larsen, Daniel Elenius Madsen, Bente Merete Stallknecht

13 Citations (Scopus)

Abstract

Methods: Haemostatic variables were investigated in 53 healthy, younger (20–40 years), moderately overweight (BMI 25–30 kg/m²) men randomly assigned to 3 months of strictly controlled endurance exercise at two different doses corresponding to an energy expenditure of 600 kcal/day (HIGH), 300 kcal/day (MOD), or to maintain their habitual lifestyle (CON). Fasting blood samples were collected before and after the intervention and analysed for thrombin generation (endogenous thrombin potential, ETP) and concentrations of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF).

Results: We observed significant within-group decreases in ETP (MOD 7 %; HIGH 6 %) and in t-PA (MOD 22 %; HIGH 21 %) and PAI-1 (MOD 16 %; HIGH 32 %) in both training groups, and no changes in the CON group. At 3 months, between-group differences were observed for ETP (p = 0.016) and t-PA (p = 0.012) due to significantly lower values in MOD and HIGH compared with CON. Borderline significant between-group differences were observed for PAI-1 (p = 0.082). A significant increase was observed in vWF in HIGH, but with no between-group differences.

Conclusions: Our results demonstrate an effect of 3 months of daily endurance exercise on biomarkers of the haemostatic balance in the direction of reduced cardiovascular risk, independent of exercise dose.

Purpose: Physical activity is associated with a decreased risk of cardiovascular disease, but dose dependency of long-term physical exercise on biomarkers within coagulation and fibrinolysis is unknown. We aimed to investigate effects of two doses of daily endurance exercise on biomarkers of the haemostatic balance in overweight men.

Original language	English
Journal	European Journal of Applied Physiology
Volume	115
Issue number	6
Pages (from-to)	1331-1338
Number of pages	8
ISSN	1439-6319
DOIs	https://doi.org/10.1007/s00421-015-3106-z
Publication status	Published - 1 Jun 2015

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Gram, A. S., Bladbjerg, E-M., Skov, J., Ploug, T., Sjödin, A., Rosenkilde Larsen, M., Madsen, D. E., & Stallknecht, B. M. (2015). Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men. European Journal of Applied Physiology, 115(6), 1331-1338. https://doi.org/10.1007/s00421-015-3106-z

Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men. / Gram, Anne Sofie; Bladbjerg, Else-Marie; Skov, Jane et al.

In: European Journal of Applied Physiology, Vol. 115, No. 6, 01.06.2015, p. 1331-1338.

Research output: Contribution to journal › Journal article › Research › peer-review

Gram, AS, Bladbjerg, E-M, Skov, J, Ploug, T , Sjödin, A, Rosenkilde Larsen, M, Madsen, DE & Stallknecht, BM 2015, 'Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men', European Journal of Applied Physiology, vol. 115, no. 6, pp. 1331-1338. https://doi.org/10.1007/s00421-015-3106-z

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title = "Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men",

abstract = "Methods: Haemostatic variables were investigated in 53 healthy, younger (20–40 years), moderately overweight (BMI 25–30 kg/m2) men randomly assigned to 3 months of strictly controlled endurance exercise at two different doses corresponding to an energy expenditure of 600 kcal/day (HIGH), 300 kcal/day (MOD), or to maintain their habitual lifestyle (CON). Fasting blood samples were collected before and after the intervention and analysed for thrombin generation (endogenous thrombin potential, ETP) and concentrations of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF).Results: We observed significant within-group decreases in ETP (MOD 7 %; HIGH 6 %) and in t-PA (MOD 22 %; HIGH 21 %) and PAI-1 (MOD 16 %; HIGH 32 %) in both training groups, and no changes in the CON group. At 3 months, between-group differences were observed for ETP (p = 0.016) and t-PA (p = 0.012) due to significantly lower values in MOD and HIGH compared with CON. Borderline significant between-group differences were observed for PAI-1 (p = 0.082). A significant increase was observed in vWF in HIGH, but with no between-group differences.Conclusions: Our results demonstrate an effect of 3 months of daily endurance exercise on biomarkers of the haemostatic balance in the direction of reduced cardiovascular risk, independent of exercise dose.Purpose: Physical activity is associated with a decreased risk of cardiovascular disease, but dose dependency of long-term physical exercise on biomarkers within coagulation and fibrinolysis is unknown. We aimed to investigate effects of two doses of daily endurance exercise on biomarkers of the haemostatic balance in overweight men.",

author = "Gram, {Anne Sofie} and Else-Marie Bladbjerg and Jane Skov and Thorkil Ploug and Anders Sj{\"o}din and {Rosenkilde Larsen}, Mads and Madsen, {Daniel Elenius} and Stallknecht, {Bente Merete}",

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T1 - Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men

AU - Gram, Anne Sofie

AU - Bladbjerg, Else-Marie

AU - Skov, Jane

AU - Ploug, Thorkil

AU - Sjödin, Anders

AU - Rosenkilde Larsen, Mads

AU - Madsen, Daniel Elenius

AU - Stallknecht, Bente Merete

N1 - CURIS 2015 NEXS 065

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Methods: Haemostatic variables were investigated in 53 healthy, younger (20–40 years), moderately overweight (BMI 25–30 kg/m2) men randomly assigned to 3 months of strictly controlled endurance exercise at two different doses corresponding to an energy expenditure of 600 kcal/day (HIGH), 300 kcal/day (MOD), or to maintain their habitual lifestyle (CON). Fasting blood samples were collected before and after the intervention and analysed for thrombin generation (endogenous thrombin potential, ETP) and concentrations of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF).Results: We observed significant within-group decreases in ETP (MOD 7 %; HIGH 6 %) and in t-PA (MOD 22 %; HIGH 21 %) and PAI-1 (MOD 16 %; HIGH 32 %) in both training groups, and no changes in the CON group. At 3 months, between-group differences were observed for ETP (p = 0.016) and t-PA (p = 0.012) due to significantly lower values in MOD and HIGH compared with CON. Borderline significant between-group differences were observed for PAI-1 (p = 0.082). A significant increase was observed in vWF in HIGH, but with no between-group differences.Conclusions: Our results demonstrate an effect of 3 months of daily endurance exercise on biomarkers of the haemostatic balance in the direction of reduced cardiovascular risk, independent of exercise dose.Purpose: Physical activity is associated with a decreased risk of cardiovascular disease, but dose dependency of long-term physical exercise on biomarkers within coagulation and fibrinolysis is unknown. We aimed to investigate effects of two doses of daily endurance exercise on biomarkers of the haemostatic balance in overweight men.

AB - Methods: Haemostatic variables were investigated in 53 healthy, younger (20–40 years), moderately overweight (BMI 25–30 kg/m2) men randomly assigned to 3 months of strictly controlled endurance exercise at two different doses corresponding to an energy expenditure of 600 kcal/day (HIGH), 300 kcal/day (MOD), or to maintain their habitual lifestyle (CON). Fasting blood samples were collected before and after the intervention and analysed for thrombin generation (endogenous thrombin potential, ETP) and concentrations of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF).Results: We observed significant within-group decreases in ETP (MOD 7 %; HIGH 6 %) and in t-PA (MOD 22 %; HIGH 21 %) and PAI-1 (MOD 16 %; HIGH 32 %) in both training groups, and no changes in the CON group. At 3 months, between-group differences were observed for ETP (p = 0.016) and t-PA (p = 0.012) due to significantly lower values in MOD and HIGH compared with CON. Borderline significant between-group differences were observed for PAI-1 (p = 0.082). A significant increase was observed in vWF in HIGH, but with no between-group differences.Conclusions: Our results demonstrate an effect of 3 months of daily endurance exercise on biomarkers of the haemostatic balance in the direction of reduced cardiovascular risk, independent of exercise dose.Purpose: Physical activity is associated with a decreased risk of cardiovascular disease, but dose dependency of long-term physical exercise on biomarkers within coagulation and fibrinolysis is unknown. We aimed to investigate effects of two doses of daily endurance exercise on biomarkers of the haemostatic balance in overweight men.

U2 - 10.1007/s00421-015-3106-z

DO - 10.1007/s00421-015-3106-z

M3 - Journal article

C2 - 25618791

SN - 1439-6319

VL - 115

SP - 1331

EP - 1338

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 6

ER -

Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men

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