TY - JOUR
T1 - Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
AU - Bartual, Sergio G
AU - Alcorlo, Martín
AU - Martínez-Caballero, Siseth
AU - Molina, Rafael
AU - Hermoso, Juan A
N1 - Copyright © 2017 Elsevier GmbH. All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.
AB - Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.
U2 - 10.1016/j.ijmm.2017.10.003
DO - 10.1016/j.ijmm.2017.10.003
M3 - Review
C2 - 29100886
SN - 1438-4221
VL - 308
SP - 692
EP - 704
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
IS - 6
ER -
