'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial

TY - JOUR

T1 - 'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial

AU - Jakobsen, Janus Christian

AU - Gluud, Christian Nyfeldt

AU - Kongerslev, Mickey Toftkjær

AU - Larsen, Kirsten Aaskov

AU - Sørensen, Per

AU - Winkel, Per

AU - Lange, Theis

AU - Søgaard, Ulf

AU - Simonsen, Erik

PY - 2012/12/19

Y1 - 2012/12/19

N2 - Background: Most interventions for depression have shown small or no effects. 'Third wave' cognitive therapy and mentalization-based therapy have both gained some ground as treatments of psychological problems. No randomised trial has compared the effects of these two interventions for patients with major depression.Methods/ design: We plan a randomised, parallel group, assessor-blinded superiority clinical trial. During two years we will include 84 consecutive adult participants diagnosed with major depressive disorder. The participants will be randomised to either 'third wave' cognitive therapy versus mentalization-based therapy. The primary outcome will be the Hamilton Rating Scale for Depression at cessation of treatment at 18 weeks. Secondary outcomes will be the proportion of patients with remission, Symptom Checklist 90 Revised, Beck's Depression Inventory, and The World Health Organisation-Five Well-being Index 1999.Discussion: Interventions for depression have until now shown relatively small effects. Our trial results will provide knowledge about the effects of two modern psychotherapeutic interventions.Trial registration: ClinicalTrials: NCT01070134.

AB - Background: Most interventions for depression have shown small or no effects. 'Third wave' cognitive therapy and mentalization-based therapy have both gained some ground as treatments of psychological problems. No randomised trial has compared the effects of these two interventions for patients with major depression.Methods/ design: We plan a randomised, parallel group, assessor-blinded superiority clinical trial. During two years we will include 84 consecutive adult participants diagnosed with major depressive disorder. The participants will be randomised to either 'third wave' cognitive therapy versus mentalization-based therapy. The primary outcome will be the Hamilton Rating Scale for Depression at cessation of treatment at 18 weeks. Secondary outcomes will be the proportion of patients with remission, Symptom Checklist 90 Revised, Beck's Depression Inventory, and The World Health Organisation-Five Well-being Index 1999.Discussion: Interventions for depression have until now shown relatively small effects. Our trial results will provide knowledge about the effects of two modern psychotherapeutic interventions.Trial registration: ClinicalTrials: NCT01070134.

U2 - 10.1186/1471-244X-12-232

DO - 10.1186/1471-244X-12-232

M3 - Journal article

C2 - 23253305

SN - 1471-244X

VL - 12

SP - 232

JO - B M C Psychiatry

JF - B M C Psychiatry

IS - 232

ER -