Thin newborns are more insulin resistant at 10 years of age

Anni Larnkjær; Helga Kristensen Ingstrup; Lene Schack-Nielsen; Christian Mølgaard; Kim F. Michaelsen

doi:10.1111/j.1651-2227.2010.02087.x

Thin newborns are more insulin resistant at 10 years of age

Anni Larnkjær, Helga Kristensen Ingstrup, Lene Schack-Nielsen, Christian Mølgaard, Kim F. Michaelsen

5 Citations (Scopus)

Abstract

Aims: To investigate the relation between ponderal index or birth weight and insulin resistance in late childhood. Methods: An observational study of 92-term appropriate-for-gestational age infants was carried out. Weight and length were measured at birth and at 9 months and duration of breast feeding was noted at 9 months. Follow-up examinations at 10 years of age included measurement of weight, height, pubertal status, fasting insulin and glucose concentrations. Results: Ponderal index at birth was negatively (B ± SE = -0.05 ± 0.02; p = 0.025) and current BMI was positively (B ± SE = 0.14 ± 0.02; p < 0.001) associated with insulin resistance measured as homeostasis model assessment (HOMA) at 10 years of age adjusted for gender and pubertal stage. Current BMI and ponderal index at birth were still significant after adjusting for weight at 9 months. Birth weight and weight at 9 months was not correlated with HOMA (p = 0.58) adjusted for current BMI, gender and pubertal stage. HOMA was higher in the tertile with the lowest ponderal index than in the two remaining tertiles (p = 0.024). Conclusion: Relative thinness at birth, but neither birth weight nor weight gain from 0-9 months, was associated with higher insulin resistance at 10 years of age in this cohort with a low prevalence of overweight at 10 years of age and normal birth weight.

Original language	English
Journal	Acta Paediatrica
Volume	100
Issue number	4
Pages (from-to)	511-514
Number of pages	4
ISSN	0803-5253
DOIs	https://doi.org/10.1111/j.1651-2227.2010.02087.x
Publication status	Published - Apr 2011

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title = "Thin newborns are more insulin resistant at 10 years of age",

abstract = "Aims: To investigate the relation between ponderal index or birth weight and insulin resistance in late childhood. Methods: An observational study of 92-term appropriate-for-gestational age infants was carried out. Weight and length were measured at birth and at 9 months and duration of breast feeding was noted at 9 months. Follow-up examinations at 10 years of age included measurement of weight, height, pubertal status, fasting insulin and glucose concentrations. Results: Ponderal index at birth was negatively (B ± SE = -0.05 ± 0.02; p = 0.025) and current BMI was positively (B ± SE = 0.14 ± 0.02; p < 0.001) associated with insulin resistance measured as homeostasis model assessment (HOMA) at 10 years of age adjusted for gender and pubertal stage. Current BMI and ponderal index at birth were still significant after adjusting for weight at 9 months. Birth weight and weight at 9 months was not correlated with HOMA (p = 0.58) adjusted for current BMI, gender and pubertal stage. HOMA was higher in the tertile with the lowest ponderal index than in the two remaining tertiles (p = 0.024). Conclusion: Relative thinness at birth, but neither birth weight nor weight gain from 0-9 months, was associated with higher insulin resistance at 10 years of age in this cohort with a low prevalence of overweight at 10 years of age and normal birth weight.",

author = "Anni Larnkj{\ae}r and Ingstrup, {Helga Kristensen} and Lene Schack-Nielsen and Christian M{\o}lgaard and Michaelsen, {Kim F.}",

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T1 - Thin newborns are more insulin resistant at 10 years of age

AU - Larnkjær, Anni

AU - Ingstrup, Helga Kristensen

AU - Schack-Nielsen, Lene

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

PY - 2011/4

Y1 - 2011/4

N2 - Aims: To investigate the relation between ponderal index or birth weight and insulin resistance in late childhood. Methods: An observational study of 92-term appropriate-for-gestational age infants was carried out. Weight and length were measured at birth and at 9 months and duration of breast feeding was noted at 9 months. Follow-up examinations at 10 years of age included measurement of weight, height, pubertal status, fasting insulin and glucose concentrations. Results: Ponderal index at birth was negatively (B ± SE = -0.05 ± 0.02; p = 0.025) and current BMI was positively (B ± SE = 0.14 ± 0.02; p < 0.001) associated with insulin resistance measured as homeostasis model assessment (HOMA) at 10 years of age adjusted for gender and pubertal stage. Current BMI and ponderal index at birth were still significant after adjusting for weight at 9 months. Birth weight and weight at 9 months was not correlated with HOMA (p = 0.58) adjusted for current BMI, gender and pubertal stage. HOMA was higher in the tertile with the lowest ponderal index than in the two remaining tertiles (p = 0.024). Conclusion: Relative thinness at birth, but neither birth weight nor weight gain from 0-9 months, was associated with higher insulin resistance at 10 years of age in this cohort with a low prevalence of overweight at 10 years of age and normal birth weight.

AB - Aims: To investigate the relation between ponderal index or birth weight and insulin resistance in late childhood. Methods: An observational study of 92-term appropriate-for-gestational age infants was carried out. Weight and length were measured at birth and at 9 months and duration of breast feeding was noted at 9 months. Follow-up examinations at 10 years of age included measurement of weight, height, pubertal status, fasting insulin and glucose concentrations. Results: Ponderal index at birth was negatively (B ± SE = -0.05 ± 0.02; p = 0.025) and current BMI was positively (B ± SE = 0.14 ± 0.02; p < 0.001) associated with insulin resistance measured as homeostasis model assessment (HOMA) at 10 years of age adjusted for gender and pubertal stage. Current BMI and ponderal index at birth were still significant after adjusting for weight at 9 months. Birth weight and weight at 9 months was not correlated with HOMA (p = 0.58) adjusted for current BMI, gender and pubertal stage. HOMA was higher in the tertile with the lowest ponderal index than in the two remaining tertiles (p = 0.024). Conclusion: Relative thinness at birth, but neither birth weight nor weight gain from 0-9 months, was associated with higher insulin resistance at 10 years of age in this cohort with a low prevalence of overweight at 10 years of age and normal birth weight.

U2 - 10.1111/j.1651-2227.2010.02087.x

DO - 10.1111/j.1651-2227.2010.02087.x

M3 - Journal article

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SN - 0803-5253

VL - 100

SP - 511

EP - 514

JO - Acta Paediatrica, International Journal of Paediatrics, Supplement

JF - Acta Paediatrica, International Journal of Paediatrics, Supplement

IS - 4

ER -

Thin newborns are more insulin resistant at 10 years of age

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