Theta activity in the left dorsal premotor cortex during action re-evaluation and motor reprogramming

TY - JOUR

T1 - Theta activity in the left dorsal premotor cortex during action re-evaluation and motor reprogramming

AU - Pellegrino, Giovanni

AU - Tomasevic, Leo

AU - Herz, Damian Marc

AU - Larsen, Kit Melissa

AU - Siebner, Hartwig Roman

PY - 2018

Y1 - 2018

N2 - The ability to rapidly adjust our actions to changes in the environment is a key function of human motor control. Previous work implicated the dorsal premotor cortex (dPMC) in the up-dating of action plans based on environmental cues. Here we used electroencephalography (EEG) to identify neural signatures of up-dating cue-action relationships in the dPMC and connected frontoparietal areas. Ten healthy subjects performed a pre-cued alternate choice task. Simple geometric shapes cued button presses with the right or left index finger. The shapes of the pre-cue and go-cue differed in two third of trials. In these incongruent trials, the go-cue prompted a re-evaluation of the pre-cued action plan, slowing response time relative to trials with identical cues. This re-evaluation selectively increased theta band activity without modifying activity in alpha and beta band. Source-based analysis revealed a widespread theta increase in dorsal and mesial frontoparietal areas, including dPMC, supplementary motor area (SMA), primary motor and posterior parietal cortices (PPC). Theta activity scaled positively with response slowing and increased more strongly when the pre-cue was invalid and required subjects to select the alternate response. Together, the results indicate that theta activity in dPMC and connected frontoparietal areas is involved in the re-adjustment of cue-induced action tendencies.

AB - The ability to rapidly adjust our actions to changes in the environment is a key function of human motor control. Previous work implicated the dorsal premotor cortex (dPMC) in the up-dating of action plans based on environmental cues. Here we used electroencephalography (EEG) to identify neural signatures of up-dating cue-action relationships in the dPMC and connected frontoparietal areas. Ten healthy subjects performed a pre-cued alternate choice task. Simple geometric shapes cued button presses with the right or left index finger. The shapes of the pre-cue and go-cue differed in two third of trials. In these incongruent trials, the go-cue prompted a re-evaluation of the pre-cued action plan, slowing response time relative to trials with identical cues. This re-evaluation selectively increased theta band activity without modifying activity in alpha and beta band. Source-based analysis revealed a widespread theta increase in dorsal and mesial frontoparietal areas, including dPMC, supplementary motor area (SMA), primary motor and posterior parietal cortices (PPC). Theta activity scaled positively with response slowing and increased more strongly when the pre-cue was invalid and required subjects to select the alternate response. Together, the results indicate that theta activity in dPMC and connected frontoparietal areas is involved in the re-adjustment of cue-induced action tendencies.

KW - Action selection

KW - Dorsal premotor cortex

KW - EEG

KW - Motor

KW - Motor reprogramming

KW - Performance

KW - Reaction time

KW - Theta

U2 - 10.3389/fnhum.2018.00364

DO - 10.3389/fnhum.2018.00364

M3 - Journal article

C2 - 30297991

AN - SCOPUS:85054835395

SN - 1662-5161

VL - 12

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

M1 - 364

ER -