Theoretical Considerations in Developing Amorphous Solid Dispersions

Riikka Laitinen; Petra Alexandra Priemel; Sachin Surwase; Kirsten Graeser; Clare J. Strachan; Holger Grohganz; Thomas Rades

doi:10.1007/978-1-4939-1598-9_2

Theoretical Considerations in Developing Amorphous Solid Dispersions

Riikka Laitinen, Petra Alexandra Priemel, Sachin Surwase, Kirsten Graeser, Clare J. Strachan, Holger Grohganz, Thomas Rades

Abstract

Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in bioavailability, can be expected, and what forms of solid dispersion have been developed in the past. In this chapter, we therefore initially define the various forms of solid dispersions, and then go on to discuss properties of pure drugs with respect to their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).

Original language	English
Title of host publication	Amorphous Solid Dispersions - Theory and Practice
Editors	Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick
Number of pages	56
Place of Publication	New York
Publisher	Springer Science+Business Media
Publication date	2014
Pages	35-90
Chapter	2
ISBN (Print)	978-1-4939-1597-2
ISBN (Electronic)	978-1-4939-1598-9
DOIs	https://doi.org/10.1007/978-1-4939-1598-9_2
Publication status	Published - 2014

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10.1007/978-1-4939-1598-9_2

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Laitinen, R., Priemel, P. A., Surwase, S., Graeser, K., Strachan, C. J., Grohganz, H., & Rades, T. (2014). Theoretical Considerations in Developing Amorphous Solid Dispersions. In N. Shah, H. Sandhu, D. S. Choi, H. Chokshi, & A. W. Malick (Eds.), Amorphous Solid Dispersions - Theory and Practice (pp. 35-90). Springer Science+Business Media. https://doi.org/10.1007/978-1-4939-1598-9_2

Theoretical Considerations in Developing Amorphous Solid Dispersions. / Laitinen, Riikka; Priemel, Petra Alexandra; Surwase, Sachin et al.
Amorphous Solid Dispersions - Theory and Practice. ed. / Navnit Shah; Harpreet Sandhu; Duk Soon Choi; Hitesh Chokshi; A. Waseem Malick. New York: Springer Science+Business Media, 2014. p. 35-90.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Laitinen, R, Priemel, PA, Surwase, S, Graeser, K, Strachan, CJ, Grohganz, H & Rades, T 2014, Theoretical Considerations in Developing Amorphous Solid Dispersions. in N Shah, H Sandhu, DS Choi, H Chokshi & AW Malick (eds), Amorphous Solid Dispersions - Theory and Practice. Springer Science+Business Media, New York, pp. 35-90. https://doi.org/10.1007/978-1-4939-1598-9_2

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Theoretical Considerations in Developing Amorphous Solid Dispersions

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