The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Philip Hallenborg; Søren Feddersen; Lise Madsen; Karsten Kristiansen

doi:10.1517/14712590802680141

The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Philip Hallenborg, Søren Feddersen, Lise Madsen, Karsten Kristiansen

Department of Biology

47 Citations (Scopus)

Abstract

BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

Original language	English
Journal	Expert Opinion On Therapeutic Targets
Volume	13
Issue number	2
Pages (from-to)	235-46
Number of pages	11
ISSN	1472-8222
DOIs	https://doi.org/10.1517/14712590802680141
Publication status	Published - 2009

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title = "The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function",

abstract = "BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.",

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year = "2009",

doi = "10.1517/14712590802680141",

language = "English",

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journal = "Expert Opinion on Therapeutic Targets",

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T1 - The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

AU - Hallenborg, Philip

AU - Feddersen, Søren

AU - Madsen, Lise

AU - Kristiansen, Karsten

PY - 2009

Y1 - 2009

N2 - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

AB - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

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DO - 10.1517/14712590802680141

M3 - Journal article

C2 - 19236241

SN - 1472-8222

VL - 13

SP - 235

EP - 246

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

IS - 2

ER -

The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Abstract

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