The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

Pratik Shah; Suk Won Choi; Riddhi Nagda; Reka Geczy; Seok Keun Cho; Yong Joo Bhang; Tae-Hwan Kim; Tae Yang Song; Phil Hyu Lee; Ju-Hee Kang; Peter Waaben Thulstrup; Morten Jannik Bjerrum; Il Lae Jung; Seong Wook Yang

doi:10.1039/c8nr06186f

The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

Pratik Shah, Suk Won Choi, Riddhi Nagda, Reka Geczy, Seok Keun Cho, Yong Joo Bhang, Tae-Hwan Kim, Tae Yang Song, Phil Hyu Lee, Ju-Hee Kang, Peter Waaben Thulstrup, Morten Jannik Bjerrum, Il Lae Jung, Seong Wook Yang

9 Citations (Scopus)

Abstract

The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

Original language	English
Journal	Nanoscale
Volume	10
Issue number	44
Pages (from-to)	20717-20722
Number of pages	6
ISSN	2040-3364
DOIs	https://doi.org/10.1039/c8nr06186f
Publication status	Published - 28 Nov 2018

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Shah, P., Choi, S. W., Nagda, R., Geczy, R., Cho, S. K., Bhang, Y. J., Kim, T.-H., Song, T. Y., Lee, P. H., Kang, J.-H., Thulstrup, P. W., Bjerrum, M. J., Jung, I. L., & Yang, S. W. (2018). The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs. Nanoscale, 10(44), 20717-20722. https://doi.org/10.1039/c8nr06186f

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title = "The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs",

abstract = "The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.",

author = "Pratik Shah and Choi, {Suk Won} and Riddhi Nagda and Reka Geczy and Cho, {Seok Keun} and Bhang, {Yong Joo} and Tae-Hwan Kim and Song, {Tae Yang} and Lee, {Phil Hyu} and Ju-Hee Kang and Thulstrup, {Peter Waaben} and Bjerrum, {Morten Jannik} and Jung, {Il Lae} and Yang, {Seong Wook}",

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doi = "10.1039/c8nr06186f",

language = "English",

volume = "10",

pages = "20717--20722",

journal = "Nanoscale",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

AU - Shah, Pratik

AU - Choi, Suk Won

AU - Nagda, Riddhi

AU - Geczy, Reka

AU - Cho, Seok Keun

AU - Bhang, Yong Joo

AU - Kim, Tae-Hwan

AU - Song, Tae Yang

AU - Lee, Phil Hyu

AU - Kang, Ju-Hee

AU - Thulstrup, Peter Waaben

AU - Bjerrum, Morten Jannik

AU - Jung, Il Lae

AU - Yang, Seong Wook

PY - 2018/11/28

Y1 - 2018/11/28

N2 - The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

AB - The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

U2 - 10.1039/c8nr06186f

DO - 10.1039/c8nr06186f

M3 - Journal article

C2 - 30398269

SN - 2040-3364

VL - 10

SP - 20717

EP - 20722

JO - Nanoscale

JF - Nanoscale

IS - 44

ER -

The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

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