The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis

Simon Metz Pedersen; Niels Chr Nielsen; Henrik J Andersen; Johan Olsson; Magnus Simrén; Lena Ohman; Ulla Svensson; Anders Malmendal; Hanne Christine S. Bertram

doi:10.3390/nu2111141

The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis

Simon Metz Pedersen, Niels Chr Nielsen, Henrik J Andersen, Johan Olsson, Magnus Simrén, Lena Ohman, Ulla Svensson, Anders Malmendal, Hanne Christine S. Bertram

Inflammation, Metabolism and Oxidation

12 Citations (Scopus)

Abstract

The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.

Original language	English
Journal	Nutrients
Volume	2
Issue number	11
Pages (from-to)	1141-55
Number of pages	15
ISSN	2072-6643
DOIs	https://doi.org/10.3390/nu2111141
Publication status	Published - Nov 2010

Keywords

3-Hydroxybutyric Acid
Adolescent
Adult
Aged
Animals
Biological Markers
Female
Humans
Irritable Bowel Syndrome
Lactic Acid
Magnetic Resonance Spectroscopy
Male
Middle Aged
Milk
Probiotics
Young Adult

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Pedersen, S. M., Nielsen, N. C., Andersen, H. J., Olsson, J., Simrén, M., Ohman, L., Svensson, U., Malmendal, A., & Bertram, H. C. S. (2010). The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis. Nutrients, 2(11), 1141-55. https://doi.org/10.3390/nu2111141

The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis. / Pedersen, Simon Metz; Nielsen, Niels Chr; Andersen, Henrik J et al.

In: Nutrients, Vol. 2, No. 11, 11.2010, p. 1141-55.

Research output: Contribution to journal › Journal article › Research › peer-review

Pedersen, SM, Nielsen, NC, Andersen, HJ, Olsson, J, Simrén, M, Ohman, L, Svensson, U, Malmendal, A & Bertram, HCS 2010, 'The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis', Nutrients, vol. 2, no. 11, pp. 1141-55. https://doi.org/10.3390/nu2111141

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title = "The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis",

abstract = "The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.",

keywords = "3-Hydroxybutyric Acid, Adolescent, Adult, Aged, Animals, Biological Markers, Female, Humans, Irritable Bowel Syndrome, Lactic Acid, Magnetic Resonance Spectroscopy, Male, Middle Aged, Milk, Probiotics, Young Adult",

author = "Pedersen, {Simon Metz} and Nielsen, {Niels Chr} and Andersen, {Henrik J} and Johan Olsson and Magnus Simr{\'e}n and Lena Ohman and Ulla Svensson and Anders Malmendal and Bertram, {Hanne Christine S.}",

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AU - Olsson, Johan

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AB - The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.

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