The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis

TY - JOUR

T1 - The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis

AU - Gartland, Alison

AU - Erler, Janine Terra

AU - Cox, Thomas Robert

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour.

AB - Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour.

KW - Journal Article

U2 - 10.1016/j.jbo.2016.04.001

DO - 10.1016/j.jbo.2016.04.001

M3 - Journal article

C2 - 27761366

SN - 2212-1366

VL - 5

SP - 100

EP - 103

JO - Journal of Bone Oncology

JF - Journal of Bone Oncology

IS - 3

ER -