The role of inflammation in the pathogenesis of glaucoma

Rupali Vohra; James C Tsai; Miriam Kolko

doi:10.1016/j.survophthal.2012.08.010

The role of inflammation in the pathogenesis of glaucoma

Rupali Vohra, James C Tsai, Miriam Kolko

105 Citations (Scopus)

Abstract

Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

Original language	English
Journal	Survey of Ophthalmology
Volume	58
Issue number	4
Pages (from-to)	311-20
Number of pages	10
ISSN	0039-6257
DOIs	https://doi.org/10.1016/j.survophthal.2012.08.010
Publication status	Published - Jul 2013

Keywords

Animals
Anoxia
Axons
Cell Death
Glaucoma
Humans
Inflammation
Oxidative Stress
Retinal Ganglion Cells

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10.1016/j.survophthal.2012.08.010

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title = "The role of inflammation in the pathogenesis of glaucoma",

abstract = "Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.",

keywords = "Animals, Anoxia, Axons, Cell Death, Glaucoma, Humans, Inflammation, Oxidative Stress, Retinal Ganglion Cells",

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T1 - The role of inflammation in the pathogenesis of glaucoma

AU - Vohra, Rupali

AU - Tsai, James C

AU - Kolko, Miriam

PY - 2013/7

Y1 - 2013/7

N2 - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

AB - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

KW - Animals

KW - Anoxia

KW - Axons

KW - Cell Death

KW - Glaucoma

KW - Humans

KW - Inflammation

KW - Oxidative Stress

KW - Retinal Ganglion Cells

U2 - 10.1016/j.survophthal.2012.08.010

DO - 10.1016/j.survophthal.2012.08.010

M3 - Journal article

C2 - 23768921

SN - 0039-6257

VL - 58

SP - 311

EP - 320

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

IS - 4

ER -

The role of inflammation in the pathogenesis of glaucoma

Abstract

Keywords

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