Abstract
Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.
| Original language | English |
|---|---|
| Journal | Free Radical Research |
| Volume | 43 |
| Issue number | 12 |
| Pages (from-to) | 1147-58 |
| Number of pages | 12 |
| ISSN | 1071-5762 |
| Publication status | Published - Dec 2009 |
| Externally published | Yes |
Keywords
- Animals
- Apoptosis
- Humans
- Oxidants
- Oxidative Stress
- Thiocyanates
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
