The role of DNA base excision repair in brain homeostasis and disease

Mansour Akbari; Marya Morevati; Deborah Croteau; Vilhelm A Bohr

doi:10.1016/j.dnarep.2015.04.029

The role of DNA base excision repair in brain homeostasis and disease

Mansour Akbari, Marya Morevati, Deborah Croteau, Vilhelm A Bohr

19 Citations (Scopus)

Abstract

Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

Original language	English
Journal	DNA Repair
Volume	32
Pages (from-to)	172-9
Number of pages	8
ISSN	1568-7864
DOIs	https://doi.org/10.1016/j.dnarep.2015.04.029
Publication status	Published - 1 Aug 2015

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10.1016/j.dnarep.2015.04.029

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title = "The role of DNA base excision repair in brain homeostasis and disease",

abstract = "Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.",

author = "Mansour Akbari and Marya Morevati and Deborah Croteau and Bohr, {Vilhelm A}",

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T1 - The role of DNA base excision repair in brain homeostasis and disease

AU - Akbari, Mansour

AU - Morevati, Marya

AU - Croteau, Deborah

AU - Bohr, Vilhelm A

N1 - Published by Elsevier B.V.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

AB - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

U2 - 10.1016/j.dnarep.2015.04.029

DO - 10.1016/j.dnarep.2015.04.029

M3 - Journal article

C2 - 26002197

SN - 1568-7864

VL - 32

SP - 172

EP - 179

JO - DNA Repair

JF - DNA Repair

ER -

The role of DNA base excision repair in brain homeostasis and disease

Abstract

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