The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

Licia P Pereira; Cristiano A Köhler; Rafael T de Sousa; Marco Solmi; Bárbara P de Freitas; Michele Fornaro; Rodrigo Machado-Vieira; Kamilla W Miskowiak; Eduard Vieta; Nicola Veronese; Brendon Stubbs; André F Carvalho

doi:10.1016/j.neubiorev.2017.05.002

The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

Licia P Pereira, Cristiano A Köhler, Rafael T de Sousa, Marco Solmi, Bárbara P de Freitas, Michele Fornaro, Rodrigo Machado-Vieira, Kamilla W Miskowiak, Eduard Vieta, Nicola Veronese, Brendon Stubbs, André F Carvalho

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Abstract

Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

Original language	English
Journal	Neuroscience & Biobehavioral Reviews
Volume	79
Pages (from-to)	87-109
ISSN	0149-7634
DOIs	https://doi.org/10.1016/j.neubiorev.2017.05.002
Publication status	Published - 1 Aug 2017

Keywords

Faculty of Social Sciences
Bipolar disorder
Genetic polymorphisms
Neuroimaging
Magnetic resonance imaging
Functional MRI
Diffusion tensor imagingvoxel based morphometry

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10.1016/j.neubiorev.2017.05.002

The_relationship_between_genetic_2017_acceptedAccepted author manuscript, 910 KBLicence: CC BY-NC-ND

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Pereira, L. P., Köhler, C. A., de Sousa, R. T., Solmi, M., de Freitas, B. P., Fornaro, M., Machado-Vieira, R., Miskowiak, K. W., Vieta, E., Veronese, N., Stubbs, B., & Carvalho, A. F. (2017). The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies. Neuroscience & Biobehavioral Reviews, 79, 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

Pereira, LP, Köhler, CA, de Sousa, RT, Solmi, M, de Freitas, BP, Fornaro, M, Machado-Vieira, R, Miskowiak, KW, Vieta, E, Veronese, N, Stubbs, B & Carvalho, AF 2017, 'The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies', Neuroscience & Biobehavioral Reviews, vol. 79, pp. 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

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title = "The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies",

abstract = "Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.",

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AU - Fornaro, Michele

AU - Machado-Vieira, Rodrigo

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AU - Vieta, Eduard

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AU - Stubbs, Brendon

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AB - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

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KW - Magnetic resonance imaging

KW - Functional MRI

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JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

ER -

The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

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Keywords

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