The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin

Stine Friis; Katiuchia Uzzun Sales; Jeffrey Martin Schafer; Lotte K Vogel; Hiroaki Kataoka; Thomas H Bugge

doi:10.1074/jbc.M114.574400

The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin

Stine Friis, Katiuchia Uzzun Sales, Jeffrey Martin Schafer, Lotte K Vogel, Hiroaki Kataoka, Thomas H Bugge

ICMM Section 8

31 Citations (Scopus)

Abstract

Background: Hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 may regulate matriptase trafficking and activation. Results: Ablation of endogenous HAI-2, but not HAI-1, causes loss of epithelial matriptase in vivo and in vitro, due to uncontrolled prostasin-dependent activation and shedding. Conclusion: HAI-2, but not HAI-1, regulates matriptase cell surface expression level. Significance: The study identifies HAI-2 as a principal regulator of prostasin-mediated matriptase activation.

Original language	English
Journal	The Journal of Biological Chemistry
Volume	289
Issue number	32
Pages (from-to)	22319-22332
Number of pages	14
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M114.574400
Publication status	Published - 8 Aug 2014

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@article{875bb2e6aeca40bf91e1c89687a69cbe,

title = "The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin",

abstract = "Background: Hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 may regulate matriptase trafficking and activation. Results: Ablation of endogenous HAI-2, but not HAI-1, causes loss of epithelial matriptase in vivo and in vitro, due to uncontrolled prostasin-dependent activation and shedding. Conclusion: HAI-2, but not HAI-1, regulates matriptase cell surface expression level. Significance: The study identifies HAI-2 as a principal regulator of prostasin-mediated matriptase activation.",

author = "Stine Friis and Sales, {Katiuchia Uzzun} and Schafer, {Jeffrey Martin} and Vogel, {Lotte K} and Hiroaki Kataoka and Bugge, {Thomas H}",

note = "Copyright {\textcopyright} 2014, The American Society for Biochemistry and Molecular Biology.",

year = "2014",

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doi = "10.1074/jbc.M114.574400",

language = "English",

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T1 - The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin

AU - Friis, Stine

AU - Sales, Katiuchia Uzzun

AU - Schafer, Jeffrey Martin

AU - Vogel, Lotte K

AU - Kataoka, Hiroaki

AU - Bugge, Thomas H

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 may regulate matriptase trafficking and activation. Results: Ablation of endogenous HAI-2, but not HAI-1, causes loss of epithelial matriptase in vivo and in vitro, due to uncontrolled prostasin-dependent activation and shedding. Conclusion: HAI-2, but not HAI-1, regulates matriptase cell surface expression level. Significance: The study identifies HAI-2 as a principal regulator of prostasin-mediated matriptase activation.

AB - Background: Hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 may regulate matriptase trafficking and activation. Results: Ablation of endogenous HAI-2, but not HAI-1, causes loss of epithelial matriptase in vivo and in vitro, due to uncontrolled prostasin-dependent activation and shedding. Conclusion: HAI-2, but not HAI-1, regulates matriptase cell surface expression level. Significance: The study identifies HAI-2 as a principal regulator of prostasin-mediated matriptase activation.

U2 - 10.1074/jbc.M114.574400

DO - 10.1074/jbc.M114.574400

M3 - Journal article

C2 - 24962579

SN - 0021-9258

VL - 289

SP - 22319

EP - 22332

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 32

ER -

The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin

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