The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design

Antonio Fernández-Ortiz; L Jesús Jiménez-Borreguero; José L Peñalvo; José M Ordovás; Agustín Mocoroa; Leticia Fernández-Friera; Martín Laclaustra; Laura García; Jesús Molina; José M Mendiguren; Beatriz López-Melgar; Vicente Martínez de Vega; Juan C Alonso-Farto; Eliseo Guallar; Henrik Sillesen; James H F Rudd; Zahi A Fayad; Borja Ibañez; Ginés Sanz; Valentín Fuster

doi:10.1016/j.ahj.2013.08.024

The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design

Antonio Fernández-Ortiz, L Jesús Jiménez-Borreguero, José L Peñalvo, José M Ordovás, Agustín Mocoroa, Leticia Fernández-Friera, Martín Laclaustra, Laura García, Jesús Molina, José M Mendiguren, Beatriz López-Melgar, Vicente Martínez de Vega, Juan C Alonso-Farto, Eliseo Guallar, Henrik Sillesen, James H F Rudd, Zahi A Fayad, Borja Ibañez, Ginés Sanz, Valentín Fuster

Department of Clinical Medicine

53 Citations (Scopus)

Abstract

Background The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined. Objective The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population. Methods The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced "omics" and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined ¹⁸F-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging (¹⁸FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the ¹⁸FDG PET/MRI study, which will be repeated at 6 years. Conclusions The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.

Original language	English
Journal	American Heart Journal
Volume	166
Issue number	6
Pages (from-to)	990–998
Number of pages	9
ISSN	0002-8703
DOIs	https://doi.org/10.1016/j.ahj.2013.08.024
Publication status	Published - Dec 2013

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Fernández-Ortiz, A., Jiménez-Borreguero, L. J., Peñalvo, J. L., Ordovás, J. M., Mocoroa, A., Fernández-Friera, L., Laclaustra, M., García, L., Molina, J., Mendiguren, J. M., López-Melgar, B., de Vega, V. M., Alonso-Farto, J. C., Guallar, E., Sillesen, H., Rudd, J. H. F., Fayad, Z. A., Ibañez, B., Sanz, G., & Fuster, V. (2013). The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design. American Heart Journal, 166(6), 990–998. https://doi.org/10.1016/j.ahj.2013.08.024

Fernández-Ortiz, A, Jiménez-Borreguero, LJ, Peñalvo, JL, Ordovás, JM, Mocoroa, A, Fernández-Friera, L, Laclaustra, M, García, L, Molina, J, Mendiguren, JM, López-Melgar, B, de Vega, VM, Alonso-Farto, JC, Guallar, E, Sillesen, H, Rudd, JHF, Fayad, ZA, Ibañez, B, Sanz, G & Fuster, V 2013, 'The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design', American Heart Journal, vol. 166, no. 6, pp. 990–998. https://doi.org/10.1016/j.ahj.2013.08.024

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title = "The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design",

abstract = "Background The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined. Objective The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population. Methods The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced {"}omics{"} and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined 18F-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging (18FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the 18FDG PET/MRI study, which will be repeated at 6 years. Conclusions The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.",

author = "Antonio Fern{\'a}ndez-Ortiz and Jim{\'e}nez-Borreguero, {L Jes{\'u}s} and Pe{\~n}alvo, {Jos{\'e} L} and Ordov{\'a}s, {Jos{\'e} M} and Agust{\'i}n Mocoroa and Leticia Fern{\'a}ndez-Friera and Mart{\'i}n Laclaustra and Laura Garc{\'i}a and Jes{\'u}s Molina and Mendiguren, {Jos{\'e} M} and Beatriz L{\'o}pez-Melgar and {de Vega}, {Vicente Mart{\'i}nez} and Alonso-Farto, {Juan C} and Eliseo Guallar and Henrik Sillesen and Rudd, {James H F} and Fayad, {Zahi A} and Borja Iba{\~n}ez and Gin{\'e}s Sanz and Valent{\'i}n Fuster",

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doi = "10.1016/j.ahj.2013.08.024",

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volume = "166",

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journal = "American Heart Journal",

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TY - JOUR

T1 - The Progression and Early detection of Subclinical Atherosclerosis (PESA) study

T2 - Rationale and design

AU - Fernández-Ortiz, Antonio

AU - Jiménez-Borreguero, L Jesús

AU - Peñalvo, José L

AU - Ordovás, José M

AU - Mocoroa, Agustín

AU - Fernández-Friera, Leticia

AU - Laclaustra, Martín

AU - García, Laura

AU - Molina, Jesús

AU - Mendiguren, José M

AU - López-Melgar, Beatriz

AU - de Vega, Vicente Martínez

AU - Alonso-Farto, Juan C

AU - Guallar, Eliseo

AU - Sillesen, Henrik

AU - Rudd, James H F

AU - Fayad, Zahi A

AU - Ibañez, Borja

AU - Sanz, Ginés

AU - Fuster, Valentín

PY - 2013/12

Y1 - 2013/12

N2 - Background The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined. Objective The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population. Methods The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced "omics" and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined 18F-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging (18FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the 18FDG PET/MRI study, which will be repeated at 6 years. Conclusions The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.

AB - Background The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined. Objective The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population. Methods The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced "omics" and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined 18F-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging (18FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the 18FDG PET/MRI study, which will be repeated at 6 years. Conclusions The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.

U2 - 10.1016/j.ahj.2013.08.024

DO - 10.1016/j.ahj.2013.08.024

M3 - Journal article

C2 - 24268213

SN - 0002-8703

VL - 166

SP - 990

EP - 998

JO - American Heart Journal

JF - American Heart Journal

IS - 6

ER -

The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: Rationale and design

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