The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Christian Haarmark; Peter R Hansen; Esben Vedel-Larsen; Sune Haahr Pedersen; Claus Graff; Mads P Andersen; Egon Toft; Fan Wang; Johannes J Struijk; Jørgen K Kanters; Christian Haarmark; Peter R Hansen; Esben Vedel-Larsen; Sune Haahr Pedersen; Claus Graff; Mads Peter Andersen; Egon Toft; Fan Wang; Johannes J. Struijk; Jørgen K Kanters

doi:10.1016/j.jelectrocard.2009.06.009

The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Christian Haarmark, Peter R Hansen, Esben Vedel-Larsen, Sune Haahr Pedersen, Claus Graff, Mads P Andersen, Egon Toft, Fan Wang, Johannes J Struijk, Jørgen K Kanters, Christian Haarmark, Peter R Hansen, Esben Vedel-Larsen, Sune Haahr Pedersen, Claus Graff, Mads Peter Andersen, Egon Toft, Fan Wang, Johannes J. Struijk, Jørgen K Kanters

Department of Clinical Medicine

104 Citations (Scopus)

Abstract

Introduction: The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic risk. TpTe was investigated before and after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). Method: Patients with first-time STEMI treated with pPCI were included (n = 101; mean age 62 years; range 39-89 years; 74% men). Digital electrocardiograms were taken pre- and post-PCI, respectively. Tpeak-Tend interval was measured in leads with limited ST-segment deviation. The primary end point was all-cause mortality during 22 ± 7 months (mean ± SD) of follow-up. Results: Pre- and post-PCI TpTe were 104 milliseconds [98-109 milliseconds] and 106 milliseconds [99-112 milliseconds], respectively (mean [95% confidence interval], P = .59). A prolonged pre-PCI TpTe was associated with increased mortality (hazard ratio, 10.5 [1.7-20.4] for a cutoff value of 100 milliseconds). Uncorrected QT and heart rate-corrected QT intervals (Fridericia-corrected QT) were prolonged after PCI (QT: 401 vs 410 milliseconds, P = .022, and Fridericia-corrected QT: 430 vs 448 milliseconds, P < .0001). Conclusion: In patients with STEMI undergoing pPCI, pre-PCI TpTe predicted subsequent all-cause mortality, and the QT interval was increased after the procedure.

Original language	English
Journal	Journal of Electrocardiology
Volume	42
Issue number	6
Pages (from-to)	555-60
Number of pages	6
ISSN	0022-0736
DOIs	https://doi.org/10.1016/j.jelectrocard.2009.06.009 https://doi.org/10.1016/j.jelectrocard.2009.06.009
Publication status	Published - Nov 2009

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Haarmark, C., Hansen, P. R., Vedel-Larsen, E., Pedersen, S. H., Graff, C., Andersen, M. P., Toft, E., Wang, F., Struijk, J. J., Kanters, J. K., Haarmark, C., Hansen, P. R., Vedel-Larsen, E., Pedersen, S. H., Graff, C., Andersen, M. P., Toft, E., Wang, F., Struijk, J. J., & Kanters, J. K. (2009). The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Journal of Electrocardiology, 42(6), 555-60. https://doi.org/10.1016/j.jelectrocard.2009.06.009, https://doi.org/10.1016/j.jelectrocard.2009.06.009

The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. / Haarmark, Christian; Hansen, Peter R; Vedel-Larsen, Esben et al.

In: Journal of Electrocardiology, Vol. 42, No. 6, 11.2009, p. 555-60.

Research output: Contribution to journal › Journal article › Research › peer-review

Haarmark, C, Hansen, PR, Vedel-Larsen, E, Pedersen, SH, Graff, C, Andersen, MP, Toft, E, Wang, F, Struijk, JJ, Kanters, JK, Haarmark, C, Hansen, PR, Vedel-Larsen, E, Pedersen, SH, Graff, C, Andersen, MP, Toft, E, Wang, F, Struijk, JJ & Kanters, JK 2009, 'The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction', Journal of Electrocardiology, vol. 42, no. 6, pp. 555-60. https://doi.org/10.1016/j.jelectrocard.2009.06.009, https://doi.org/10.1016/j.jelectrocard.2009.06.009

Haarmark C, Hansen PR, Vedel-Larsen E, Pedersen SH, Graff C, Andersen MP et al. The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Journal of Electrocardiology. 2009 Nov;42(6):555-60. doi: 10.1016/j.jelectrocard.2009.06.009, http://dx.doi.org/10.1016/j.jelectrocard.2009.06.009

@article{07c34e40359a11df8ed1000ea68e967b,

title = "The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction",

abstract = "Introduction: The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic risk. TpTe was investigated before and after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). Method: Patients with first-time STEMI treated with pPCI were included (n = 101; mean age 62 years; range 39-89 years; 74% men). Digital electrocardiograms were taken pre- and post-PCI, respectively. Tpeak-Tend interval was measured in leads with limited ST-segment deviation. The primary end point was all-cause mortality during 22 ± 7 months (mean ± SD) of follow-up. Results: Pre- and post-PCI TpTe were 104 milliseconds [98-109 milliseconds] and 106 milliseconds [99-112 milliseconds], respectively (mean [95% confidence interval], P = .59). A prolonged pre-PCI TpTe was associated with increased mortality (hazard ratio, 10.5 [1.7-20.4] for a cutoff value of 100 milliseconds). Uncorrected QT and heart rate-corrected QT intervals (Fridericia-corrected QT) were prolonged after PCI (QT: 401 vs 410 milliseconds, P = .022, and Fridericia-corrected QT: 430 vs 448 milliseconds, P < .0001). Conclusion: In patients with STEMI undergoing pPCI, pre-PCI TpTe predicted subsequent all-cause mortality, and the QT interval was increased after the procedure.",

author = "Christian Haarmark and Hansen, {Peter R} and Esben Vedel-Larsen and Pedersen, {Sune Haahr} and Claus Graff and Andersen, {Mads P} and Egon Toft and Fan Wang and Struijk, {Johannes J} and Kanters, {J{\o}rgen K} and Christian Haarmark and Hansen, {Peter R} and Esben Vedel-Larsen and Pedersen, {Sune Haahr} and Claus Graff and Andersen, {Mads Peter} and Egon Toft and Fan Wang and Struijk, {Johannes J.} and Kanters, {J{\o}rgen K}",

note = "Keywords: Adult; Aged; Angioplasty, Transluminal, Percutaneous Coronary; Denmark; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Survival Analysis; Survival Rate; Treatment Outcome",

year = "2009",

month = nov,

doi = "10.1016/j.jelectrocard.2009.06.009",

language = "English",

volume = "42",

pages = "555--60",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

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TY - JOUR

T1 - The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

AU - Haarmark, Christian

AU - Hansen, Peter R

AU - Vedel-Larsen, Esben

AU - Pedersen, Sune Haahr

AU - Graff, Claus

AU - Andersen, Mads P

AU - Toft, Egon

AU - Wang, Fan

AU - Struijk, Johannes J

AU - Kanters, Jørgen K

AU - Haarmark, Christian

AU - Hansen, Peter R

AU - Vedel-Larsen, Esben

AU - Pedersen, Sune Haahr

AU - Graff, Claus

AU - Andersen, Mads Peter

AU - Toft, Egon

AU - Wang, Fan

AU - Struijk, Johannes J.

AU - Kanters, Jørgen K

N1 - Keywords: Adult; Aged; Angioplasty, Transluminal, Percutaneous Coronary; Denmark; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Survival Analysis; Survival Rate; Treatment Outcome

PY - 2009/11

Y1 - 2009/11

N2 - Introduction: The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic risk. TpTe was investigated before and after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). Method: Patients with first-time STEMI treated with pPCI were included (n = 101; mean age 62 years; range 39-89 years; 74% men). Digital electrocardiograms were taken pre- and post-PCI, respectively. Tpeak-Tend interval was measured in leads with limited ST-segment deviation. The primary end point was all-cause mortality during 22 ± 7 months (mean ± SD) of follow-up. Results: Pre- and post-PCI TpTe were 104 milliseconds [98-109 milliseconds] and 106 milliseconds [99-112 milliseconds], respectively (mean [95% confidence interval], P = .59). A prolonged pre-PCI TpTe was associated with increased mortality (hazard ratio, 10.5 [1.7-20.4] for a cutoff value of 100 milliseconds). Uncorrected QT and heart rate-corrected QT intervals (Fridericia-corrected QT) were prolonged after PCI (QT: 401 vs 410 milliseconds, P = .022, and Fridericia-corrected QT: 430 vs 448 milliseconds, P < .0001). Conclusion: In patients with STEMI undergoing pPCI, pre-PCI TpTe predicted subsequent all-cause mortality, and the QT interval was increased after the procedure.

AB - Introduction: The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic risk. TpTe was investigated before and after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). Method: Patients with first-time STEMI treated with pPCI were included (n = 101; mean age 62 years; range 39-89 years; 74% men). Digital electrocardiograms were taken pre- and post-PCI, respectively. Tpeak-Tend interval was measured in leads with limited ST-segment deviation. The primary end point was all-cause mortality during 22 ± 7 months (mean ± SD) of follow-up. Results: Pre- and post-PCI TpTe were 104 milliseconds [98-109 milliseconds] and 106 milliseconds [99-112 milliseconds], respectively (mean [95% confidence interval], P = .59). A prolonged pre-PCI TpTe was associated with increased mortality (hazard ratio, 10.5 [1.7-20.4] for a cutoff value of 100 milliseconds). Uncorrected QT and heart rate-corrected QT intervals (Fridericia-corrected QT) were prolonged after PCI (QT: 401 vs 410 milliseconds, P = .022, and Fridericia-corrected QT: 430 vs 448 milliseconds, P < .0001). Conclusion: In patients with STEMI undergoing pPCI, pre-PCI TpTe predicted subsequent all-cause mortality, and the QT interval was increased after the procedure.

U2 - 10.1016/j.jelectrocard.2009.06.009

DO - 10.1016/j.jelectrocard.2009.06.009

M3 - Journal article

C2 - 19643432

SN - 0022-0736

VL - 42

SP - 555

EP - 560

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 6

ER -

The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

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