The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome

TY - JOUR

T1 - The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome

AU - Pihl, Kasper

AU - Larsen, Torben

AU - Rasmussen, Steen

AU - Krebs, Lone

AU - Christiansen, Michael

N1 - Keywords: Adolescent; Adult; Biological Markers; Blood Proteins; Case-Control Studies; False Positive Reactions; Female; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Infant, Small for Gestational Age; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Prognosis; Protein Precursors; Proteoglycans; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To establish the first trimester serum levels of the proform of eosinophil major basic protein (proMBP) in pregnancies with adverse outcome. Furthermore, to determine the screening performance using proMBP alone and in combination with other first trimester markers. METHODS: A case-control study was conducted in a primary hospital setting. The proMBP concentration was measured in cases with small-for-gestational age (SGA) (n = 150), spontaneous preterm delivery (n = 88), preeclampsia (n = 40), gestational hypertension (n = 10) and in controls (n = 500). Concentrations were converted to multiples of the median (MoM) in controls and groups were compared using Mann-Whitney U-test. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcome. Screening performance was assessed using receiver operating characteristic curves. RESULTS: The proMBP median was significantly reduced in pregnancies with SGA (0.81 MoM), spontaneous preterm delivery (0.83 MoM), preeclampsia (0.88 MoM) and gestational hypertension (0.60 MoM). The best screening performance was found for preeclampsia including the covariates proMBP and nulliparity yielding an area under the curve equal to 0.737 (p < 0.0005) and a 75% detection rate for a 30% false positive rate. CONCLUSION: The proMBP is a novel first trimester serum marker for adverse pregnancy outcome.

AB - OBJECTIVE: To establish the first trimester serum levels of the proform of eosinophil major basic protein (proMBP) in pregnancies with adverse outcome. Furthermore, to determine the screening performance using proMBP alone and in combination with other first trimester markers. METHODS: A case-control study was conducted in a primary hospital setting. The proMBP concentration was measured in cases with small-for-gestational age (SGA) (n = 150), spontaneous preterm delivery (n = 88), preeclampsia (n = 40), gestational hypertension (n = 10) and in controls (n = 500). Concentrations were converted to multiples of the median (MoM) in controls and groups were compared using Mann-Whitney U-test. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcome. Screening performance was assessed using receiver operating characteristic curves. RESULTS: The proMBP median was significantly reduced in pregnancies with SGA (0.81 MoM), spontaneous preterm delivery (0.83 MoM), preeclampsia (0.88 MoM) and gestational hypertension (0.60 MoM). The best screening performance was found for preeclampsia including the covariates proMBP and nulliparity yielding an area under the curve equal to 0.737 (p < 0.0005) and a 75% detection rate for a 30% false positive rate. CONCLUSION: The proMBP is a novel first trimester serum marker for adverse pregnancy outcome.

U2 - 10.1002/pd.2331

DO - 10.1002/pd.2331

M3 - Journal article

C2 - 19626619

SN - 0197-3851

VL - 29

SP - 1013

EP - 1019

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 11

ER -