The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project

Roger S. McIntyre; Hanna O Woldeyohannes; Joanna K Soczynska; Maj Vinberg; Danielle S Cha; Yena Lee; Laura Ashley Gallaugher; Roman S Dale; Mohammad T Alsuwaidan; Rodrigo B Mansur; David J Muzina; André F Carvalho; Sidney H Kennedy

doi:10.1177/2040622315627805

The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project

Roger S. McIntyre, Hanna O Woldeyohannes, Joanna K Soczynska, Maj Vinberg, Danielle S Cha, Yena Lee, Laura Ashley Gallaugher, Roman S Dale, Mohammad T Alsuwaidan, Rodrigo B Mansur, David J Muzina, André F Carvalho, Sidney H Kennedy

Department of Clinical Medicine

24 Citations (Scopus)

Abstract

OBJECTIVES: The aim of the study was to evaluate the prevalence of and illness characteristics in adults with major depressive disorder (MDD) with anxious distress specifier (ADS) enrolled in the International Mood Disorders Collaborative Project, which is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Canada and the Cleveland Clinic, Cleveland, Ohio, USA.

METHODS: Data from participants who met criteria for a current major depressive episode as part of MDD (n = 830) were included in this post hoc analysis. Diagnostic and Statistical Manual Version-5-defined ADS was operationalized as the presence of at least two out of three proxy items instead of two out of five specifiers.

RESULTS: A total of 464 individuals (i.e. 56%) met criteria for ADS. There were no between-group differences in sociodemographic variables (e.g. gender, employment, marital status). Greater severity of illness was observed in adults with ADS as evidenced by a higher number of hospitalizations, higher rates of suicidal ideation, greater depressive symptom severity, greater workplace impairment, decreased quality of life, and greater self-reported cognitive impairment.

CONCLUSIONS: Our findings underscore the importance of evaluating ADS in adults with MDD as its presence identifies a subpopulation with greater illness-associated burden and hazards.

Original language	English
Journal	Therapeutic Advances in Chronic Disease
Volume	7
Issue number	3
Pages (from-to)	153-159
Number of pages	7
ISSN	2040-6223
DOIs	https://doi.org/10.1177/2040622315627805
Publication status	Published - May 2016

Keywords

Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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McIntyre, R. S., Woldeyohannes, H. O., Soczynska, J. K., Vinberg, M., Cha, D. S., Lee, Y., Gallaugher, L. A., Dale, R. S., Alsuwaidan, M. T., Mansur, R. B., Muzina, D. J., Carvalho, A. F., & Kennedy, S. H. (2016). The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project. Therapeutic Advances in Chronic Disease, 7(3), 153-159. https://doi.org/10.1177/2040622315627805

The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder : results from the International Mood Disorders Collaborative Project. / McIntyre, Roger S.; Woldeyohannes, Hanna O; Soczynska, Joanna K et al.

In: Therapeutic Advances in Chronic Disease, Vol. 7, No. 3, 05.2016, p. 153-159.

Research output: Contribution to journal › Journal article › Research › peer-review

McIntyre, RS, Woldeyohannes, HO, Soczynska, JK, Vinberg, M, Cha, DS, Lee, Y, Gallaugher, LA, Dale, RS, Alsuwaidan, MT, Mansur, RB, Muzina, DJ, Carvalho, AF & Kennedy, SH 2016, 'The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project', Therapeutic Advances in Chronic Disease, vol. 7, no. 3, pp. 153-159. https://doi.org/10.1177/2040622315627805

McIntyre RS, Woldeyohannes HO, Soczynska JK, Vinberg M, Cha DS, Lee Y et al. The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder: results from the International Mood Disorders Collaborative Project. Therapeutic Advances in Chronic Disease. 2016 May;7(3):153-159. doi: 10.1177/2040622315627805

McIntyre, Roger S. ; Woldeyohannes, Hanna O ; Soczynska, Joanna K et al. / The prevalence and clinical characteristics associated with Diagnostic and Statistical Manual Version-5-defined anxious distress specifier in adults with major depressive disorder : results from the International Mood Disorders Collaborative Project. In: Therapeutic Advances in Chronic Disease. 2016 ; Vol. 7, No. 3. pp. 153-159.

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