Abstract
Biological research of Sus scrofa, the domestic pig, is of immediate relevance for food production sciences, and for developing pig as a model organism for human biomedical research. Publicly available data repositories play a fundamental role for all biological sciences, and protein data repositories are in particular essential for the successful development of new proteomic methods. Cumulative proteome data repositories, including the PeptideAtlas, provide the means for targeted proteomics, system-wide observations, and cross-species observational studies, but pigs have so far been underrepresented in existing repositories. We here present a significantly improved build of the Pig PeptideAtlas, which includes pig proteome data from 25 tissues and three body fluid types mapped to 7139 canonical proteins. The content of the Pig PeptideAtlas reflects actively ongoing research within the veterinary proteomics domain, and this article demonstrates how the expression of isoform-unique peptides can be observed across distinct tissues and body fluids. The Pig PeptideAtlas is a unique resource for use in animal proteome research, particularly biomarker discovery and for preliminary design of SRM assays, which are equally important for progress in research that supports farm animal production and veterinary health, as for developing pig models with relevance to human health research.
| Original language | English |
|---|---|
| Journal | Proteomics |
| Volume | 16 |
| Issue number | 4 |
| Pages (from-to) | 634-644 |
| Number of pages | 11 |
| ISSN | 1615-9853 |
| DOIs | |
| Publication status | Published - 1 Feb 2016 |
Keywords
- Amino Acid Sequence
- Animals
- Data Mining
- Databases, Protein
- Inflammation
- Mass Spectrometry
- Metabolic Networks and Pathways
- Protein Isoforms
- Proteome
- Proteomics
- Serum Amyloid A Protein
- Sus scrofa
- Swine
- Swine Diseases
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
