The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients:  A double-blind, randomised, sham-controlled trial revisited  with focus on the patient-reported outcomes.

Per Bech; Maria Gefke; Marianne Anita Lunde; Lise Lauritzen; Klaus Per Juul Martiny

doi:10.1155/2011/806298

The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes.

Per Bech, Maria Gefke, Marianne Anita Lunde, Lise Lauritzen, Klaus Per Juul Martiny

11 Citations (Scopus)

Abstract

Background. Our T-PEMF trial has been revisited with focus on the pharmacopsychometric triangle in which effect size is used when comparing wanted versus unwanted clinical effects and quality of life as outcomes. In this analysis, we have especially focused on the self-reported HAM-D Methods. The antidepressive medication which the patients were resistant to was kept unchanged during the five weeks of active versus sham T-PEMF. Results. In total 21, patients received active T-PEMF, and 19 patients received sham T-PEMF. The effect size was 1.02 and 0.90, respectively, on HAM-Dand HAM-DS. Concerning side effects, the active T-PEMF reduced the baseline score on concentration problems with an effect size of 0.44 while inducing more autonomic symptoms than sham T-PEMF with an effect size of -0.41. The advantage of active over sham T-PEMF obtained an effect size of 0.48. Conclusion. Active T-PEMF was found superior to sham T-PEMF within the pharmacopsychometric triangle with a clinically significant effect size level above 0.40.

Original language	English
Journal	Depression Research and Treatment
Number of pages	6
DOIs	https://doi.org/10.1155/2011/806298
Publication status	Published - 4 Dec 2011

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Bech, P., Gefke, M., Lunde, M. A., Lauritzen, L., & Martiny, K. P. J. (2011). The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes. Depression Research and Treatment. https://doi.org/10.1155/2011/806298

The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes. / Bech, Per; Gefke, Maria; Lunde, Marianne Anita et al.
In: Depression Research and Treatment, 04.12.2011.

Research output: Contribution to journal › Journal article › Research › peer-review

Bech, P, Gefke, M, Lunde, MA, Lauritzen, L & Martiny, KPJ 2011, 'The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes.', Depression Research and Treatment. https://doi.org/10.1155/2011/806298

Bech P, Gefke M, Lunde MA, Lauritzen L, Martiny KPJ. The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes. Depression Research and Treatment. 2011 Dec 4. doi: 10.1155/2011/806298

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title = "The pharmacopsychometric triangle to illustrate the effectiveness of T-PEMF concomitant with antidepressants in treatment resistant patients: A double-blind, randomised, sham-controlled trial revisited with focus on the patient-reported outcomes.",

abstract = "Background. Our T-PEMF trial has been revisited with focus on the pharmacopsychometric triangle in which effect size is used when comparing wanted versus unwanted clinical effects and quality of life as outcomes. In this analysis, we have especially focused on the self-reported HAM-D Methods. The antidepressive medication which the patients were resistant to was kept unchanged during the five weeks of active versus sham T-PEMF. Results. In total 21, patients received active T-PEMF, and 19 patients received sham T-PEMF. The effect size was 1.02 and 0.90, respectively, on HAM-Dand HAM-DS. Concerning side effects, the active T-PEMF reduced the baseline score on concentration problems with an effect size of 0.44 while inducing more autonomic symptoms than sham T-PEMF with an effect size of -0.41. The advantage of active over sham T-PEMF obtained an effect size of 0.48. Conclusion. Active T-PEMF was found superior to sham T-PEMF within the pharmacopsychometric triangle with a clinically significant effect size level above 0.40.",

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AB - Background. Our T-PEMF trial has been revisited with focus on the pharmacopsychometric triangle in which effect size is used when comparing wanted versus unwanted clinical effects and quality of life as outcomes. In this analysis, we have especially focused on the self-reported HAM-D Methods. The antidepressive medication which the patients were resistant to was kept unchanged during the five weeks of active versus sham T-PEMF. Results. In total 21, patients received active T-PEMF, and 19 patients received sham T-PEMF. The effect size was 1.02 and 0.90, respectively, on HAM-Dand HAM-DS. Concerning side effects, the active T-PEMF reduced the baseline score on concentration problems with an effect size of 0.44 while inducing more autonomic symptoms than sham T-PEMF with an effect size of -0.41. The advantage of active over sham T-PEMF obtained an effect size of 0.48. Conclusion. Active T-PEMF was found superior to sham T-PEMF within the pharmacopsychometric triangle with a clinically significant effect size level above 0.40.

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