The paradox of systemic vasodilatation and sympathetic nervous stimulation in space

Peter Norsk; Niels Juel Christensen

doi:10.1016/j.resp.2009.07.020

The paradox of systemic vasodilatation and sympathetic nervous stimulation in space

Peter Norsk, Niels Juel Christensen

Renal and Vascular Research

19 Citations (Scopus)

Abstract

Cardiac output is increased by some 18% by weightlessness during the initial week of spaceflight compared to upright standing or sitting on the ground and more so during the initial days of flight than at the end. In addition, mean 24-h diastolic, but not systolic pressure, is significantly decreased by 5mmHg. This is in accordance with observations that very acute weightlessness during parabolic airplane flights and a week of weightlessness in space leads to a decrease in systemic vascular resistance. That the arterial resistance vessels are dilated in space is in contrast to the augmented sympathetic nervous activity and decreased urine production, which have consistently been observed in astronauts in space. These contrasting observations require further investigation.

Original language	English
Journal	Respiratory Physiology & Neurobiology
Volume	169 Suppl 1
Pages (from-to)	S26-9
ISSN	1569-9048
DOIs	https://doi.org/10.1016/j.resp.2009.07.020
Publication status	Published - 2009

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10.1016/j.resp.2009.07.020

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title = "The paradox of systemic vasodilatation and sympathetic nervous stimulation in space",

abstract = "Cardiac output is increased by some 18% by weightlessness during the initial week of spaceflight compared to upright standing or sitting on the ground and more so during the initial days of flight than at the end. In addition, mean 24-h diastolic, but not systolic pressure, is significantly decreased by 5mmHg. This is in accordance with observations that very acute weightlessness during parabolic airplane flights and a week of weightlessness in space leads to a decrease in systemic vascular resistance. That the arterial resistance vessels are dilated in space is in contrast to the augmented sympathetic nervous activity and decreased urine production, which have consistently been observed in astronauts in space. These contrasting observations require further investigation.",

author = "Peter Norsk and Christensen, {Niels Juel}",

note = "Keywords: Adaptation, Physiological; Bed Rest; Blood Pressure; Cardiac Output; Humans; Peptides; Space Flight; Sympathetic Nervous System; Vasodilation; Weightlessness",

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AU - Norsk, Peter

AU - Christensen, Niels Juel

N1 - Keywords: Adaptation, Physiological; Bed Rest; Blood Pressure; Cardiac Output; Humans; Peptides; Space Flight; Sympathetic Nervous System; Vasodilation; Weightlessness

PY - 2009

Y1 - 2009

N2 - Cardiac output is increased by some 18% by weightlessness during the initial week of spaceflight compared to upright standing or sitting on the ground and more so during the initial days of flight than at the end. In addition, mean 24-h diastolic, but not systolic pressure, is significantly decreased by 5mmHg. This is in accordance with observations that very acute weightlessness during parabolic airplane flights and a week of weightlessness in space leads to a decrease in systemic vascular resistance. That the arterial resistance vessels are dilated in space is in contrast to the augmented sympathetic nervous activity and decreased urine production, which have consistently been observed in astronauts in space. These contrasting observations require further investigation.

AB - Cardiac output is increased by some 18% by weightlessness during the initial week of spaceflight compared to upright standing or sitting on the ground and more so during the initial days of flight than at the end. In addition, mean 24-h diastolic, but not systolic pressure, is significantly decreased by 5mmHg. This is in accordance with observations that very acute weightlessness during parabolic airplane flights and a week of weightlessness in space leads to a decrease in systemic vascular resistance. That the arterial resistance vessels are dilated in space is in contrast to the augmented sympathetic nervous activity and decreased urine production, which have consistently been observed in astronauts in space. These contrasting observations require further investigation.

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VL - 169 Suppl 1

SP - S26-9

JO - Respiratory Physiology & Neurobiology

JF - Respiratory Physiology & Neurobiology

ER -

The paradox of systemic vasodilatation and sympathetic nervous stimulation in space

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