The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

Anna Vilborg; Jacob-Andreas Harald Glahder; Margareta T Wilhelm; Cinzia Bersani; Martin Corcoran; Salah Mahmoudi; Maiken Rosenstierne; Dan Grandér; Marianne Farnebo; Bodil Norrild; Klas G Wiman

doi:10.1073/pnas.0900862106

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

Anna Vilborg, Jacob-Andreas Harald Glahder, Margareta T Wilhelm, Cinzia Bersani, Martin Corcoran, Salah Mahmoudi, Maiken Rosenstierne, Dan Grandér, Marianne Farnebo, Bodil Norrild, Klas G Wiman

63 Citations (Scopus)

Abstract

The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.

Original language	English
Journal	Proceedings of the National Academy of Science of the United States of America
Volume	106
Issue number	37
Pages (from-to)	15756-61
Number of pages	5
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.0900862106
Publication status	Published - 2009

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Vilborg, A., Glahder, J-A. H., Wilhelm, M. T., Bersani, C., Corcoran, M., Mahmoudi, S., Rosenstierne, M., Grandér, D., Farnebo, M., Norrild, B., & Wiman, K. G. (2009). The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element. Proceedings of the National Academy of Science of the United States of America, 106(37), 15756-61. https://doi.org/10.1073/pnas.0900862106

Vilborg, A, Glahder, J-AH, Wilhelm, MT, Bersani, C, Corcoran, M, Mahmoudi, S, Rosenstierne, M, Grandér, D, Farnebo, M, Norrild, B & Wiman, KG 2009, 'The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element', Proceedings of the National Academy of Science of the United States of America, vol. 106, no. 37, pp. 15756-61. https://doi.org/10.1073/pnas.0900862106

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title = "The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element",

abstract = "The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.",

author = "Anna Vilborg and Glahder, {Jacob-Andreas Harald} and Wilhelm, {Margareta T} and Cinzia Bersani and Martin Corcoran and Salah Mahmoudi and Maiken Rosenstierne and Dan Grand{\'e}r and Marianne Farnebo and Bodil Norrild and Wiman, {Klas G}",

note = "Keywords: 3' Untranslated Regions; Animals; Base Composition; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; Feedback, Physiological; Genes, p53; Humans; Mice; NIH 3T3 Cells; Nuclear Proteins; RNA Stability; RNA, Messenger; RNA, Small Interfering; Stress, Physiological; Tumor Suppressor Protein p53",

year = "2009",

doi = "10.1073/pnas.0900862106",

language = "English",

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pages = "15756--61",

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AU - Vilborg, Anna

AU - Glahder, Jacob-Andreas Harald

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AU - Bersani, Cinzia

AU - Corcoran, Martin

AU - Mahmoudi, Salah

AU - Rosenstierne, Maiken

AU - Grandér, Dan

AU - Farnebo, Marianne

AU - Norrild, Bodil

AU - Wiman, Klas G

N1 - Keywords: 3' Untranslated Regions; Animals; Base Composition; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; Feedback, Physiological; Genes, p53; Humans; Mice; NIH 3T3 Cells; Nuclear Proteins; RNA Stability; RNA, Messenger; RNA, Small Interfering; Stress, Physiological; Tumor Suppressor Protein p53

PY - 2009

Y1 - 2009

N2 - The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.

AB - The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.

U2 - 10.1073/pnas.0900862106

DO - 10.1073/pnas.0900862106

M3 - Journal article

C2 - 19805223

SN - 0027-8424

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EP - 15761

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 37

ER -

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

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