The origins and processing of ultra fine anaphase DNA bridges

Ying Liu; Christian Thomas Friberg Nielsen; Qi Yao; Ian D Hickson

doi:10.1016/j.gde.2014.03.003

The origins and processing of ultra fine anaphase DNA bridges

Ying Liu, Christian Thomas Friberg Nielsen, Qi Yao, Ian D Hickson

65 Citations (Scopus)

Abstract

Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.

Original language	English
Journal	Current Opinion in Genetics & Development
Volume	26C
Pages (from-to)	1-5
Number of pages	5
ISSN	0959-437X
DOIs	https://doi.org/10.1016/j.gde.2014.03.003
Publication status	Published - Jun 2014

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title = "The origins and processing of ultra fine anaphase DNA bridges",

abstract = "Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.",

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AU - Liu, Ying

AU - Nielsen, Christian Thomas Friberg

AU - Yao, Qi

AU - Hickson, Ian D

PY - 2014/6

Y1 - 2014/6

N2 - Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.

AB - Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.

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DO - 10.1016/j.gde.2014.03.003

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VL - 26C

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JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

ER -

The origins and processing of ultra fine anaphase DNA bridges

Abstract

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