The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group

Mikkel Østergaard; Charles G. Peterfy; Paul Bird; Frédérique Gandjbakhch; Daniel Glinatsi; Iris Eshed; Espen A. Haavardsholm; Siri Lillegraven; Pernille Bøyesen; Bo Ejbjerg; Violaine Foltz; Paul Emery; Harry K. Genant; Philip G. Conaghan

doi:10.3899/jrheum.161433

The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group

Mikkel Østergaard^*, Charles G. Peterfy, Paul Bird, Frédérique Gandjbakhch, Daniel Glinatsi, Iris Eshed, Espen A. Haavardsholm, Siri Lillegraven, Pernille Bøyesen, Bo Ejbjerg, Violaine Foltz, Paul Emery, Harry K. Genant, Philip G. Conaghan

^*Corresponding author for this work

Department of Clinical Medicine

56 Citations (Scopus)

Abstract

Objective: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results: Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion: Updated 2016 RAMRIS recommendations and a research agenda were developed. The Journal of Rheumatology

Original language	English
Journal	Journal of Rheumatology
Volume	44
Issue number	11
Pages (from-to)	1706-1712
Number of pages	7
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.161433
Publication status	Published - 1 Nov 2017

Keywords

Magnetic resonance imaging rheumatoid arthritis
Omeract
Outcome assessment

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10.3899/jrheum.161433

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Østergaard, M., Peterfy, C. G., Bird, P., Gandjbakhch, F., Glinatsi, D., Eshed, I., Haavardsholm, E. A., Lillegraven, S., Bøyesen, P., Ejbjerg, B., Foltz, V., Emery, P., Genant, H. K., & Conaghan, P. G. (2017). The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group. Journal of Rheumatology, 44(11), 1706-1712. https://doi.org/10.3899/jrheum.161433

The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system : Updated recommendations by the OMERACT MRI in arthritis working group. / Østergaard, Mikkel; Peterfy, Charles G.; Bird, Paul et al.

In: Journal of Rheumatology, Vol. 44, No. 11, 01.11.2017, p. 1706-1712.

Research output: Contribution to journal › Journal article › Research › peer-review

Østergaard, M, Peterfy, CG, Bird, P, Gandjbakhch, F, Glinatsi, D, Eshed, I, Haavardsholm, EA, Lillegraven, S, Bøyesen, P, Ejbjerg, B, Foltz, V, Emery, P, Genant, HK & Conaghan, PG 2017, 'The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group', Journal of Rheumatology, vol. 44, no. 11, pp. 1706-1712. https://doi.org/10.3899/jrheum.161433

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title = "The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group",

abstract = "Objective: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results: Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion: Updated 2016 RAMRIS recommendations and a research agenda were developed. The Journal of Rheumatology",

keywords = "Magnetic resonance imaging rheumatoid arthritis, Omeract, Outcome assessment",

author = "Mikkel {\O}stergaard and Peterfy, {Charles G.} and Paul Bird and Fr{\'e}d{\'e}rique Gandjbakhch and Daniel Glinatsi and Iris Eshed and Haavardsholm, {Espen A.} and Siri Lillegraven and Pernille B{\o}yesen and Bo Ejbjerg and Violaine Foltz and Paul Emery and Genant, {Harry K.} and Conaghan, {Philip G.}",

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doi = "10.3899/jrheum.161433",

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T2 - Updated recommendations by the OMERACT MRI in arthritis working group

AU - Østergaard, Mikkel

AU - Peterfy, Charles G.

AU - Bird, Paul

AU - Gandjbakhch, Frédérique

AU - Glinatsi, Daniel

AU - Eshed, Iris

AU - Haavardsholm, Espen A.

AU - Lillegraven, Siri

AU - Bøyesen, Pernille

AU - Ejbjerg, Bo

AU - Foltz, Violaine

AU - Emery, Paul

AU - Genant, Harry K.

AU - Conaghan, Philip G.

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N2 - Objective: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results: Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion: Updated 2016 RAMRIS recommendations and a research agenda were developed. The Journal of Rheumatology

AB - Objective: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results: Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion: Updated 2016 RAMRIS recommendations and a research agenda were developed. The Journal of Rheumatology

KW - Magnetic resonance imaging rheumatoid arthritis

KW - Omeract

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DO - 10.3899/jrheum.161433

M3 - Journal article

C2 - 28811353

AN - SCOPUS:85032619113

SN - 0315-162X

VL - 44

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JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 11

ER -

The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group

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Keywords

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