The molecular and morphogenetic basis of pancreas organogenesis

TY - JOUR

T1 - The molecular and morphogenetic basis of pancreas organogenesis

AU - Larsen, Hjalte List

AU - Grapin-Botton, Anne

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/6

Y1 - 2017/6

N2 - The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions. Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. We elaborate on how these processes are orchestrated in space and coordinated with morphogenesis. We draw mainly from experiments conducted in the mouse model but also from investigations in other model organisms, complementing a recent comprehensive review of human pancreas development (Jennings et al., 2015) [1]. The understanding of pancreas development in model organisms provides a framework to interpret how human mutations lead to neonatal diabetes and may contribute to other forms of diabetes and to guide the production of desired pancreatic cell types from pluripotent stem cells for therapeutic purposes.

AB - The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions. Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. We elaborate on how these processes are orchestrated in space and coordinated with morphogenesis. We draw mainly from experiments conducted in the mouse model but also from investigations in other model organisms, complementing a recent comprehensive review of human pancreas development (Jennings et al., 2015) [1]. The understanding of pancreas development in model organisms provides a framework to interpret how human mutations lead to neonatal diabetes and may contribute to other forms of diabetes and to guide the production of desired pancreatic cell types from pluripotent stem cells for therapeutic purposes.

U2 - 10.1016/j.semcdb.2017.01.005

DO - 10.1016/j.semcdb.2017.01.005

M3 - Journal article

C2 - 28089869

SN - 1084-9521

VL - 66

SP - 51

EP - 68

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -