The metabolic syndrome in HIV

Signe W Worm; Jens D Lundgren

doi:10.1016/j.beem.2010.10.018

The metabolic syndrome in HIV

Signe W Worm, Jens D Lundgren

Department of Immunology and Microbiology

21 Citations (Scopus)

Abstract

The metabolic syndrome (MS) is a term used to describe the clustering of risk factors for cardiovascular disease (CVD), including elevated triglyceride (TG), low high density lipoprotein cholesterol (HDL), hypertension, hyperglycemia/ insulin resistance and intra-abdominal obesity. This paper discusses why the prevalence of MS in the setting of HIV has been reported to range from 7-45% and how antiretroviral drugs might contribute to the development of MS. The MS has been reported to be a 'CVD risk enhancer', and much debate is ongoing on the independent risk of CVD associated with the MS. Based on a limited number of studies on MS in HIV with clinical end-points, there is no data to support that the MS is independently associated with an increased risk of CVD.

Original language	English
Journal	Best Practice & Research: Clinical Endocrinology & Metabolism
Volume	25
Issue number	3
Pages (from-to)	479-86
Number of pages	8
ISSN	1521-690X
DOIs	https://doi.org/10.1016/j.beem.2010.10.018
Publication status	Published - 1 Jun 2011

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10.1016/j.beem.2010.10.018

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abstract = "The metabolic syndrome (MS) is a term used to describe the clustering of risk factors for cardiovascular disease (CVD), including elevated triglyceride (TG), low high density lipoprotein cholesterol (HDL), hypertension, hyperglycemia/ insulin resistance and intra-abdominal obesity. This paper discusses why the prevalence of MS in the setting of HIV has been reported to range from 7-45% and how antiretroviral drugs might contribute to the development of MS. The MS has been reported to be a 'CVD risk enhancer', and much debate is ongoing on the independent risk of CVD associated with the MS. Based on a limited number of studies on MS in HIV with clinical end-points, there is no data to support that the MS is independently associated with an increased risk of CVD.",

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The metabolic syndrome in HIV

Abstract

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