The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial

Anna Banck-Petersen; Cecilie K Olsen; Sissal S Djurhuus; Anita Herrstedt; Sarah Thorsen-Streit; Mathias Ried-Larsen; Kell Østerlind; Jens Osterkamp; Peter-Martin Krarup; Kirsten Vistisen; Camilla S Mosgaard; Bente K Pedersen; Pernille Højman; Jesper F Christensen

doi:10.1016/j.conctc.2018.01.008

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial

Anna Banck-Petersen, Cecilie K Olsen, Sissal S Djurhuus, Anita Herrstedt, Sarah Thorsen-Streit, Mathias Ried-Larsen, Kell Østerlind, Jens Osterkamp, Peter-Martin Krarup, Kirsten Vistisen, Camilla S Mosgaard, Bente K Pedersen, Pernille Højman, Jesper F Christensen

Department of Clinical Medicine

4 Citations (Scopus)

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Abstract

Background: Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The “Interval Walking in Colorectal Cancer“(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study. Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st 2015, and February 1st 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P < 0.001) and more likely to be working (OR 5.04; 95%CI 1.96–12.98, P < 0.001) than non-participants. Conclusion: In the present study, recruitment of CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

Original language	English
Journal	Contemporary Clinical Trials Communications
Volume	9
Pages (from-to)	143-150
Number of pages	8
ISSN	2451-8654
DOIs	https://doi.org/10.1016/j.conctc.2018.01.008
Publication status	Published - Mar 2018

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Banck-Petersen, A., Olsen, C. K., Djurhuus, S. S., Herrstedt, A., Thorsen-Streit, S., Ried-Larsen, M., Østerlind, K., Osterkamp, J., Krarup, P-M., Vistisen, K., Mosgaard, C. S., Pedersen, B. K., Højman, P., & Christensen, J. F. (2018). The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial. Contemporary Clinical Trials Communications, 9, 143-150. https://doi.org/10.1016/j.conctc.2018.01.008

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study : Design, methods and recruitment results of a randomized controlled feasibility trial. / Banck-Petersen, Anna; Olsen, Cecilie K; Djurhuus, Sissal S et al.

In: Contemporary Clinical Trials Communications, Vol. 9, 03.2018, p. 143-150.

Research output: Contribution to journal › Journal article › Research › peer-review

Banck-Petersen, A, Olsen, CK, Djurhuus, SS, Herrstedt, A, Thorsen-Streit, S, Ried-Larsen, M, Østerlind, K, Osterkamp, J, Krarup, P-M, Vistisen, K, Mosgaard, CS, Pedersen, BK, Højman, P & Christensen, JF 2018, 'The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial', Contemporary Clinical Trials Communications, vol. 9, pp. 143-150. https://doi.org/10.1016/j.conctc.2018.01.008

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title = "The {"}Interval Walking in Colorectal Cancer{"} (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial",

abstract = "Background: Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The “Interval Walking in Colorectal Cancer“(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study. Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st 2015, and February 1st 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P < 0.001) and more likely to be working (OR 5.04; 95%CI 1.96–12.98, P < 0.001) than non-participants. Conclusion: In the present study, recruitment of CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.",

author = "Anna Banck-Petersen and Olsen, {Cecilie K} and Djurhuus, {Sissal S} and Anita Herrstedt and Sarah Thorsen-Streit and Mathias Ried-Larsen and Kell {\O}sterlind and Jens Osterkamp and Peter-Martin Krarup and Kirsten Vistisen and Mosgaard, {Camilla S} and Pedersen, {Bente K} and Pernille H{\o}jman and Christensen, {Jesper F}",

year = "2018",

month = mar,

doi = "10.1016/j.conctc.2018.01.008",

language = "English",

volume = "9",

pages = "143--150",

journal = "Contemporary Clinical Trials Communications",

issn = "2451-8654",

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TY - JOUR

T1 - The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study

T2 - Design, methods and recruitment results of a randomized controlled feasibility trial

AU - Banck-Petersen, Anna

AU - Olsen, Cecilie K

AU - Djurhuus, Sissal S

AU - Herrstedt, Anita

AU - Thorsen-Streit, Sarah

AU - Ried-Larsen, Mathias

AU - Østerlind, Kell

AU - Osterkamp, Jens

AU - Krarup, Peter-Martin

AU - Vistisen, Kirsten

AU - Mosgaard, Camilla S

AU - Pedersen, Bente K

AU - Højman, Pernille

AU - Christensen, Jesper F

PY - 2018/3

Y1 - 2018/3

N2 - Background: Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The “Interval Walking in Colorectal Cancer“(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study. Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st 2015, and February 1st 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P < 0.001) and more likely to be working (OR 5.04; 95%CI 1.96–12.98, P < 0.001) than non-participants. Conclusion: In the present study, recruitment of CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

AB - Background: Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The “Interval Walking in Colorectal Cancer“(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study. Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st 2015, and February 1st 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P < 0.001) and more likely to be working (OR 5.04; 95%CI 1.96–12.98, P < 0.001) than non-participants. Conclusion: In the present study, recruitment of CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

U2 - 10.1016/j.conctc.2018.01.008

DO - 10.1016/j.conctc.2018.01.008

M3 - Journal article

C2 - 29696237

SN - 2451-8654

VL - 9

SP - 143

EP - 150

JO - Contemporary Clinical Trials Communications

JF - Contemporary Clinical Trials Communications

ER -

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial

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