The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment

T Zimmermann-Belsing; A Juul; J Juul Holst; U Feldt-Rasmussen

doi:http://dx.doi.org/10.1016/j.ghir.2003.12.015

The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment

T Zimmermann-Belsing, A Juul, J Juul Holst, U Feldt-Rasmussen

12 Citations (Scopus)

Abstract

Hyperthyroidism is associated with altered growth hormone (GH) secretion. Many patients with thyroid dysfunction experience several poorly described complications such as symptoms and signs also seen in patients with growth hormone deficiency (GHD). We have therefore prospectively evaluated a possible relationship between the thyroid function, body composition, leptin levels and insulin-like growth factor (IGF) related peptides in patients with Graves' disease. DESIGN, PATIENTS, AND MEASUREMENTS: In a prospective group of 24 fasting female patients with Graves' disease (mean age (CI 95%): 40 years (33-47)), we measured serum thyroxine, triiodothyronine, thyrotropine (TSH), TSH receptor antibodies, anti-thyroid peroxidase, leptin, body composition, body mass index (BMI) and IGF-related peptides at diagnosis and after 12 months of treatment with thiamazol (ATD).

Original language	English
Journal	Growth Hormone & I G F Research
Volume	14
Issue number	3
Pages (from-to)	235-44
Number of pages	10
ISSN	1096-6374
DOIs	https://doi.org/10.1016/j.ghir.2003.12.015
Publication status	Published - 2004

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title = "The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment",

abstract = "Hyperthyroidism is associated with altered growth hormone (GH) secretion. Many patients with thyroid dysfunction experience several poorly described complications such as symptoms and signs also seen in patients with growth hormone deficiency (GHD). We have therefore prospectively evaluated a possible relationship between the thyroid function, body composition, leptin levels and insulin-like growth factor (IGF) related peptides in patients with Graves' disease. DESIGN, PATIENTS, AND MEASUREMENTS: In a prospective group of 24 fasting female patients with Graves' disease (mean age (CI 95%): 40 years (33-47)), we measured serum thyroxine, triiodothyronine, thyrotropine (TSH), TSH receptor antibodies, anti-thyroid peroxidase, leptin, body composition, body mass index (BMI) and IGF-related peptides at diagnosis and after 12 months of treatment with thiamazol (ATD).",

author = "T Zimmermann-Belsing and A Juul and {Juul Holst}, J and U Feldt-Rasmussen",

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TY - JOUR

T1 - The insulin-like growth axis in patients with autoimmune thyrotoxicosis

T2 - effect of antithyroid drug treatment

AU - Zimmermann-Belsing, T

AU - Juul, A

AU - Juul Holst, J

AU - Feldt-Rasmussen, U

PY - 2004

Y1 - 2004

N2 - Hyperthyroidism is associated with altered growth hormone (GH) secretion. Many patients with thyroid dysfunction experience several poorly described complications such as symptoms and signs also seen in patients with growth hormone deficiency (GHD). We have therefore prospectively evaluated a possible relationship between the thyroid function, body composition, leptin levels and insulin-like growth factor (IGF) related peptides in patients with Graves' disease. DESIGN, PATIENTS, AND MEASUREMENTS: In a prospective group of 24 fasting female patients with Graves' disease (mean age (CI 95%): 40 years (33-47)), we measured serum thyroxine, triiodothyronine, thyrotropine (TSH), TSH receptor antibodies, anti-thyroid peroxidase, leptin, body composition, body mass index (BMI) and IGF-related peptides at diagnosis and after 12 months of treatment with thiamazol (ATD).

AB - Hyperthyroidism is associated with altered growth hormone (GH) secretion. Many patients with thyroid dysfunction experience several poorly described complications such as symptoms and signs also seen in patients with growth hormone deficiency (GHD). We have therefore prospectively evaluated a possible relationship between the thyroid function, body composition, leptin levels and insulin-like growth factor (IGF) related peptides in patients with Graves' disease. DESIGN, PATIENTS, AND MEASUREMENTS: In a prospective group of 24 fasting female patients with Graves' disease (mean age (CI 95%): 40 years (33-47)), we measured serum thyroxine, triiodothyronine, thyrotropine (TSH), TSH receptor antibodies, anti-thyroid peroxidase, leptin, body composition, body mass index (BMI) and IGF-related peptides at diagnosis and after 12 months of treatment with thiamazol (ATD).

U2 - http://dx.doi.org/10.1016/j.ghir.2003.12.015

DO - http://dx.doi.org/10.1016/j.ghir.2003.12.015

M3 - Journal article

SN - 1096-6374

VL - 14

SP - 235

EP - 244

JO - Growth Hormone & I G F Research

JF - Growth Hormone & I G F Research

IS - 3

ER -

The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment

Abstract

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