The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Lise Giorgis-allemand; Marie Pedersen; Claire Bernard; Inmaculada Aguilera; Rob M. J. Beelen; Leda Chatzi; Marta Cirach; Asta Danileviciute; Audrius Dedele; Manon Van Eijsden; Marisa Estarlich; Ana Fernández-somoano; Mariana F. Fernández; Francesco Forastiere; Ulrike Gehring; Regina Grazuleviciene; Olena Gruzieva; Barbara Heude; Gerard Hoek; Kees De Hoogh; Edith H. Van Den Hooven; Siri E. Håberg; Carmen Iñiguez; Vincent W. V. Jaddoe; Michal Korek; Aitana Lertxundi; Johanna Lepeule; Per Nafstad; Wenche Nystad; Evridiki Patelarou; Daniela Porta; Dirkje Postma; Ole Raaschou-nielsen; Peter Rudnai; Valérie Siroux; Jordi Sunyer; Euripides Stephanou; Mette Sørensen; Kirsten Thorup Eriksen; Derek Tuffnell; Mihály J. Varró; Tanja G. M. Vrijkotte; Alet Wijga; John Wright; Mark J. Nieuwenhuijsen; Göran Pershagen; Bert Brunekreef; Manolis Kogevinas; Rémy Slama

doi:10.1093/aje/kww141

The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Lise Giorgis-allemand, Marie Pedersen, Claire Bernard, Inmaculada Aguilera, Rob M. J. Beelen, Leda Chatzi, Marta Cirach, Asta Danileviciute, Audrius Dedele, Manon Van Eijsden, Marisa Estarlich, Ana Fernández-somoano, Mariana F. Fernández, Francesco Forastiere, Ulrike Gehring, Regina Grazuleviciene, Olena Gruzieva, Barbara Heude, Gerard Hoek, Kees De HooghEdith H. Van Den Hooven, Siri E. Håberg, Carmen Iñiguez, Vincent W. V. Jaddoe, Michal Korek, Aitana Lertxundi, Johanna Lepeule, Per Nafstad, Wenche Nystad, Evridiki Patelarou, Daniela Porta, Dirkje Postma, Ole Raaschou-nielsen, Peter Rudnai, Valérie Siroux, Jordi Sunyer, Euripides Stephanou, Mette Sørensen, Kirsten Thorup Eriksen, Derek Tuffnell, Mihály J. Varró, Tanja G. M. Vrijkotte, Alet Wijga, John Wright, Mark J. Nieuwenhuijsen, Göran Pershagen, Bert Brunekreef, Manolis Kogevinas, Rémy Slama

31 Citations (Scopus)

Abstract

Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994–2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the −5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.

Original language	English
Journal	American Journal of Epidemiology
Volume	185
Issue number	4
Pages (from-to)	247–258
Number of pages	12
ISSN	0002-9262
DOIs	https://doi.org/10.1093/aje/kww141
Publication status	Published - 1 Feb 2017
Externally published	Yes

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Giorgis-allemand, L., Pedersen, M., Bernard, C., Aguilera, I., Beelen, R. M. J., Chatzi, L., Cirach, M., Danileviciute, A., Dedele, A., Van Eijsden, M., Estarlich, M., Fernández-somoano, A., Fernández, M. F., Forastiere, F., Gehring, U., Grazuleviciene, R., Gruzieva, O., Heude, B., Hoek, G., ... Slama, R. (2017). The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth. American Journal of Epidemiology, 185(4), 247–258. https://doi.org/10.1093/aje/kww141

Giorgis-allemand, L, Pedersen, M, Bernard, C, Aguilera, I, Beelen, RMJ, Chatzi, L, Cirach, M, Danileviciute, A, Dedele, A, Van Eijsden, M, Estarlich, M, Fernández-somoano, A, Fernández, MF, Forastiere, F, Gehring, U, Grazuleviciene, R, Gruzieva, O, Heude, B, Hoek, G, De Hoogh, K, Van Den Hooven, EH, Håberg, SE, Iñiguez, C, Jaddoe, VWV, Korek, M, Lertxundi, A, Lepeule, J, Nafstad, P, Nystad, W, Patelarou, E, Porta, D, Postma, D, Raaschou-nielsen, O, Rudnai, P, Siroux, V, Sunyer, J, Stephanou, E, Sørensen, M, Eriksen, KT, Tuffnell, D, Varró, MJ, Vrijkotte, TGM, Wijga, A, Wright, J, Nieuwenhuijsen, MJ, Pershagen, G, Brunekreef, B, Kogevinas, M & Slama, R 2017, 'The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth', American Journal of Epidemiology, vol. 185, no. 4, pp. 247–258. https://doi.org/10.1093/aje/kww141

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abstract = "Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994–2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the −5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.",

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AU - Giorgis-allemand, Lise

AU - Pedersen, Marie

AU - Bernard, Claire

AU - Aguilera, Inmaculada

AU - Beelen, Rob M. J.

AU - Chatzi, Leda

AU - Cirach, Marta

AU - Danileviciute, Asta

AU - Dedele, Audrius

AU - Van Eijsden, Manon

AU - Estarlich, Marisa

AU - Fernández-somoano, Ana

AU - Fernández, Mariana F.

AU - Forastiere, Francesco

AU - Gehring, Ulrike

AU - Grazuleviciene, Regina

AU - Gruzieva, Olena

AU - Heude, Barbara

AU - Hoek, Gerard

AU - De Hoogh, Kees

AU - Van Den Hooven, Edith H.

AU - Håberg, Siri E.

AU - Iñiguez, Carmen

AU - Jaddoe, Vincent W. V.

AU - Korek, Michal

AU - Lertxundi, Aitana

AU - Lepeule, Johanna

AU - Nafstad, Per

AU - Nystad, Wenche

AU - Patelarou, Evridiki

AU - Porta, Daniela

AU - Postma, Dirkje

AU - Raaschou-nielsen, Ole

AU - Rudnai, Peter

AU - Siroux, Valérie

AU - Sunyer, Jordi

AU - Stephanou, Euripides

AU - Sørensen, Mette

AU - Eriksen, Kirsten Thorup

AU - Tuffnell, Derek

AU - Varró, Mihály J.

AU - Vrijkotte, Tanja G. M.

AU - Wijga, Alet

AU - Wright, John

AU - Nieuwenhuijsen, Mark J.

AU - Pershagen, Göran

AU - Brunekreef, Bert

AU - Kogevinas, Manolis

AU - Slama, Rémy

PY - 2017/2/1

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N2 - Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994–2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the −5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.

AB - Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994–2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the −5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.

U2 - 10.1093/aje/kww141

DO - 10.1093/aje/kww141

M3 - Journal article

C2 - 28087514

SN - 0002-9262

VL - 185

SP - 247

EP - 258

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 4

ER -

The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Abstract

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