The importance of environment on respiratory genotype/phenotype relationships in the Inuit

P V Candelaria; V Backer; S-K Khoo; J A Bizzintino; C M Hayden; G Baynam; I A Laing; G Zhang; C Porsbjerg; J Goldblatt; P N Le Souëf; Greenlandic Study Population Group

doi:10.1111/j.1398-9995.2009.02145.x

The importance of environment on respiratory genotype/phenotype relationships in the Inuit

P V Candelaria, V Backer, S-K Khoo, J A Bizzintino, C M Hayden, G Baynam, I A Laing, G Zhang, C Porsbjerg, J Goldblatt, P N Le Souëf, Greenlandic Study Population Group

6 Citations (Scopus)

Abstract

Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit.

Original language	English
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	65
Issue number	2
Pages (from-to)	229-37
Number of pages	9
ISSN	0105-4538
DOIs	https://doi.org/10.1111/j.1398-9995.2009.02145.x
Publication status	Published - 1 Feb 2010

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Candelaria, P. V., Backer, V., Khoo, S-K., Bizzintino, J. A., Hayden, C. M., Baynam, G., Laing, I. A., Zhang, G., Porsbjerg, C., Goldblatt, J., Le Souëf, P. N., & Greenlandic Study Population Group (2010). The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy: European Journal of Allergy and Clinical Immunology, 65(2), 229-37. https://doi.org/10.1111/j.1398-9995.2009.02145.x

Candelaria, PV, Backer, V, Khoo, S-K, Bizzintino, JA, Hayden, CM, Baynam, G, Laing, IA, Zhang, G, Porsbjerg, C, Goldblatt, J, Le Souëf, PN & Greenlandic Study Population Group 2010, 'The importance of environment on respiratory genotype/phenotype relationships in the Inuit', Allergy: European Journal of Allergy and Clinical Immunology, vol. 65, no. 2, pp. 229-37. https://doi.org/10.1111/j.1398-9995.2009.02145.x

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title = "The importance of environment on respiratory genotype/phenotype relationships in the Inuit",

abstract = "Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit.",

author = "Candelaria, {P V} and V Backer and S-K Khoo and Bizzintino, {J A} and Hayden, {C M} and G Baynam and Laing, {I A} and G Zhang and C Porsbjerg and J Goldblatt and {Le Sou{\"e}f}, {P N} and Vibeke Backer",

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AU - Backer, V

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AU - Bizzintino, J A

AU - Hayden, C M

AU - Baynam, G

AU - Laing, I A

AU - Zhang, G

AU - Porsbjerg, C

AU - Goldblatt, J

AU - Le Souëf, P N

AU - Greenlandic Study Population Group

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N2 - Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit.

AB - Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit.

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DO - 10.1111/j.1398-9995.2009.02145.x

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

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ER -

The importance of environment on respiratory genotype/phenotype relationships in the Inuit

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