The impact of ultraviolet therapy on stratum corneum ceramides and barrier function

TY - JOUR

T1 - The impact of ultraviolet therapy on stratum corneum ceramides and barrier function

AU - Jungersted, Jakob Mutanu

AU - Høgh, Julie Kaae

AU - Hellgren, Lars

AU - Jemec, Gregor

AU - Agner, Tove

N1 - © 2011 John Wiley & Sons A/S.

PY - 2011/12

Y1 - 2011/12

N2 - The ceramide profile as well as the barrier function is known to be deteriorated in atopic eczema and psoriasis, and ultraviolet (UV) light is known to improve the barrier function. The impact of UV light on ceramides, however, is not clarified. The aim of this study was to examine the effect of UV therapy in dermatological patients on ceramides and skin barrier function. We found that UV light treatment does not change the ratio of important stratum corneum lipids, but we confirm earlier findings of decreased susceptibility to irritants after UV- therapy.

AB - The ceramide profile as well as the barrier function is known to be deteriorated in atopic eczema and psoriasis, and ultraviolet (UV) light is known to improve the barrier function. The impact of UV light on ceramides, however, is not clarified. The aim of this study was to examine the effect of UV therapy in dermatological patients on ceramides and skin barrier function. We found that UV light treatment does not change the ratio of important stratum corneum lipids, but we confirm earlier findings of decreased susceptibility to irritants after UV- therapy.

U2 - 10.1111/j.1600-0781.2011.00618.x

DO - 10.1111/j.1600-0781.2011.00618.x

M3 - Journal article

SN - 0905-4383

VL - 27

SP - 331

EP - 333

JO - Photodermatology Photoimmunology and Photomedicine

JF - Photodermatology Photoimmunology and Photomedicine

IS - 6

ER -