The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial

Santiago Navas-Carretero; Claus Holst; Wim H Saris; Marleen A van Baak; Susan A Jebb; Anthony Kafatos; Angeliki Papadaki; Andreas F H Pfeiffer; Teodora Handjieva-Darlenska; Petr Hlavaty; Steen Stender; Thomas Meinert Larsen; Arne Astrup; J Alfredo Martinez

doi:10.1080/07315724.2014.948642

The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial

Santiago Navas-Carretero, Claus Holst, Wim H Saris, Marleen A van Baak, Susan A Jebb, Anthony Kafatos, Angeliki Papadaki, Andreas F H Pfeiffer, Teodora Handjieva-Darlenska, Petr Hlavaty, Steen Stender, Thomas Meinert Larsen, Arne Astrup, J Alfredo Martinez

6 Citations (Scopus)

Abstract

OBJECTIVE: Maintenance of weight loss and associated cardiovascular benefits after following energy-restricted diets is still a challenging field, and thorough investigation is needed. The present research aimed to determine the role of protein and gender in relation to two different intervention models related to food supply, in a weight maintenance trial.

SUBJECTS AND METHODS: The DiOGenes trial was a long-term, multicenter, randomized, dietary intervention study, conducted in eight European countries (Clinical Trials.gov, NCT00390637), focusing on assessing the effectiveness of weight maintenance over 6 months. This secondary analysis intended to evaluate the different benefits for weight maintenance and cardiometabolic markers of two dietary advice delivery models: "shop + instruction intervention" vs "instruction-alone intervention," which were further categorized for gender and macronutrient intake.

RESULTS: The weight maintenance intervention based on different macronutrient intake showed, independently of the advice delivery model, in both sexes that higher protein consumption was more effective for weight stability, showing better results in obese women (low protein: 1.65 kg in males and 0.73 Kg in females vs high protein: 1.45 kg in males and -0.93 Kg in females) . Measurements concerning cardiovascular risk markers from subjects on both structured models produced similar trends in the subsequent follow-up period, with a lower rebound in women for most of the markers analyzed.

CONCLUSION: The reported dietary benefits for weight sustainability should be ascribed to the macronutrient distribution (higher protein diets) rather than to the structured mode of delivery. Higher weight regain in males was noted, as well as a metabolic divergence attributable to the sex, with a better biochemical outcome in women.

Original language	English
Journal	Journal of the American College of Nutrition
Volume	35
Issue number	1
Pages (from-to)	20-30
Number of pages	11
ISSN	0731-5724
DOIs	https://doi.org/10.1080/07315724.2014.948642
Publication status	Published - 2 Jan 2016

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Navas-Carretero, S., Holst, C., Saris, W. H., van Baak, M. A., Jebb, S. A., Kafatos, A., Papadaki, A., Pfeiffer, A. F. H., Handjieva-Darlenska, T., Hlavaty, P., Stender, S., Larsen, T. M., Astrup, A., & Martinez, J. A. (2016). The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial. Journal of the American College of Nutrition, 35(1), 20-30. https://doi.org/10.1080/07315724.2014.948642

The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision : The DiOGenes randomized trial. / Navas-Carretero, Santiago; Holst, Claus; Saris, Wim H et al.

In: Journal of the American College of Nutrition, Vol. 35, No. 1, 02.01.2016, p. 20-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Navas-Carretero, S, Holst, C, Saris, WH, van Baak, MA, Jebb, SA, Kafatos, A, Papadaki, A, Pfeiffer, AFH, Handjieva-Darlenska, T, Hlavaty, P, Stender, S, Larsen, TM, Astrup, A & Martinez, JA 2016, 'The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial', Journal of the American College of Nutrition, vol. 35, no. 1, pp. 20-30. https://doi.org/10.1080/07315724.2014.948642

Navas-Carretero S, Holst C, Saris WH, van Baak MA, Jebb SA, Kafatos A et al. The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial. Journal of the American College of Nutrition. 2016 Jan 2;35(1):20-30. doi: 10.1080/07315724.2014.948642

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title = "The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial",

abstract = "OBJECTIVE: Maintenance of weight loss and associated cardiovascular benefits after following energy-restricted diets is still a challenging field, and thorough investigation is needed. The present research aimed to determine the role of protein and gender in relation to two different intervention models related to food supply, in a weight maintenance trial.SUBJECTS AND METHODS: The DiOGenes trial was a long-term, multicenter, randomized, dietary intervention study, conducted in eight European countries (Clinical Trials.gov, NCT00390637), focusing on assessing the effectiveness of weight maintenance over 6 months. This secondary analysis intended to evaluate the different benefits for weight maintenance and cardiometabolic markers of two dietary advice delivery models: {"}shop + instruction intervention{"} vs {"}instruction-alone intervention,{"} which were further categorized for gender and macronutrient intake.RESULTS: The weight maintenance intervention based on different macronutrient intake showed, independently of the advice delivery model, in both sexes that higher protein consumption was more effective for weight stability, showing better results in obese women (low protein: 1.65 kg in males and 0.73 Kg in females vs high protein: 1.45 kg in males and -0.93 Kg in females) . Measurements concerning cardiovascular risk markers from subjects on both structured models produced similar trends in the subsequent follow-up period, with a lower rebound in women for most of the markers analyzed.CONCLUSION: The reported dietary benefits for weight sustainability should be ascribed to the macronutrient distribution (higher protein diets) rather than to the structured mode of delivery. Higher weight regain in males was noted, as well as a metabolic divergence attributable to the sex, with a better biochemical outcome in women.",

author = "Santiago Navas-Carretero and Claus Holst and Saris, {Wim H} and {van Baak}, {Marleen A} and Jebb, {Susan A} and Anthony Kafatos and Angeliki Papadaki and Pfeiffer, {Andreas F H} and Teodora Handjieva-Darlenska and Petr Hlavaty and Steen Stender and Larsen, {Thomas Meinert} and Arne Astrup and Martinez, {J Alfredo}",

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T1 - The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision

T2 - The DiOGenes randomized trial

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AU - Holst, Claus

AU - Saris, Wim H

AU - van Baak, Marleen A

AU - Jebb, Susan A

AU - Kafatos, Anthony

AU - Papadaki, Angeliki

AU - Pfeiffer, Andreas F H

AU - Handjieva-Darlenska, Teodora

AU - Hlavaty, Petr

AU - Stender, Steen

AU - Larsen, Thomas Meinert

AU - Astrup, Arne

AU - Martinez, J Alfredo

N1 - CURIS 2016 NEXS 001

PY - 2016/1/2

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N2 - OBJECTIVE: Maintenance of weight loss and associated cardiovascular benefits after following energy-restricted diets is still a challenging field, and thorough investigation is needed. The present research aimed to determine the role of protein and gender in relation to two different intervention models related to food supply, in a weight maintenance trial.SUBJECTS AND METHODS: The DiOGenes trial was a long-term, multicenter, randomized, dietary intervention study, conducted in eight European countries (Clinical Trials.gov, NCT00390637), focusing on assessing the effectiveness of weight maintenance over 6 months. This secondary analysis intended to evaluate the different benefits for weight maintenance and cardiometabolic markers of two dietary advice delivery models: "shop + instruction intervention" vs "instruction-alone intervention," which were further categorized for gender and macronutrient intake.RESULTS: The weight maintenance intervention based on different macronutrient intake showed, independently of the advice delivery model, in both sexes that higher protein consumption was more effective for weight stability, showing better results in obese women (low protein: 1.65 kg in males and 0.73 Kg in females vs high protein: 1.45 kg in males and -0.93 Kg in females) . Measurements concerning cardiovascular risk markers from subjects on both structured models produced similar trends in the subsequent follow-up period, with a lower rebound in women for most of the markers analyzed.CONCLUSION: The reported dietary benefits for weight sustainability should be ascribed to the macronutrient distribution (higher protein diets) rather than to the structured mode of delivery. Higher weight regain in males was noted, as well as a metabolic divergence attributable to the sex, with a better biochemical outcome in women.

AB - OBJECTIVE: Maintenance of weight loss and associated cardiovascular benefits after following energy-restricted diets is still a challenging field, and thorough investigation is needed. The present research aimed to determine the role of protein and gender in relation to two different intervention models related to food supply, in a weight maintenance trial.SUBJECTS AND METHODS: The DiOGenes trial was a long-term, multicenter, randomized, dietary intervention study, conducted in eight European countries (Clinical Trials.gov, NCT00390637), focusing on assessing the effectiveness of weight maintenance over 6 months. This secondary analysis intended to evaluate the different benefits for weight maintenance and cardiometabolic markers of two dietary advice delivery models: "shop + instruction intervention" vs "instruction-alone intervention," which were further categorized for gender and macronutrient intake.RESULTS: The weight maintenance intervention based on different macronutrient intake showed, independently of the advice delivery model, in both sexes that higher protein consumption was more effective for weight stability, showing better results in obese women (low protein: 1.65 kg in males and 0.73 Kg in females vs high protein: 1.45 kg in males and -0.93 Kg in females) . Measurements concerning cardiovascular risk markers from subjects on both structured models produced similar trends in the subsequent follow-up period, with a lower rebound in women for most of the markers analyzed.CONCLUSION: The reported dietary benefits for weight sustainability should be ascribed to the macronutrient distribution (higher protein diets) rather than to the structured mode of delivery. Higher weight regain in males was noted, as well as a metabolic divergence attributable to the sex, with a better biochemical outcome in women.

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The impact of gender and protein intake on the success of weight maintenance and associated cardiovascular risk benefits, independent of the mode of food provision: The DiOGenes randomized trial

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