The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men

TY - JOUR

T1 - The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men

AU - Haugaard, S B

AU - Andersen, O

AU - Hansen, T W

AU - Eugen-Olsen, J

AU - Linneberg, A

AU - Madsbad, S

AU - Olsen, M H

AU - Jørgensen, T

AU - Borch-Johnsen, Knut

AU - Jeppesen, J

N1 - Journal compilation © 2011 Diabetes UK.

PY - 2012/4

Y1 - 2012/4

N2 - Aim: To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation. This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort. Methods: The Danish National Diabetes Register enabled more accurate identification of incident diabetes during a median follow-up of 13.8 years in the Danish MONICA 10 cohort (n = 2353 generally healthy individuals). The soluble urokinase plasminogen activator receptor was measured by the ELISA method. To fulfil model assumptions, outcome analyses were stratified by age, and further by smoking, owing to the interaction between the soluble urokinase plasminogen activator receptor and smoking on new-onset diabetes (P

AB - Aim: To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation. This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort. Methods: The Danish National Diabetes Register enabled more accurate identification of incident diabetes during a median follow-up of 13.8 years in the Danish MONICA 10 cohort (n = 2353 generally healthy individuals). The soluble urokinase plasminogen activator receptor was measured by the ELISA method. To fulfil model assumptions, outcome analyses were stratified by age, and further by smoking, owing to the interaction between the soluble urokinase plasminogen activator receptor and smoking on new-onset diabetes (P

U2 - 10.1111/j.1464-5491.2011.03513.x

DO - 10.1111/j.1464-5491.2011.03513.x

M3 - Journal article

C2 - 22050462

SN - 0742-3071

VL - 29

SP - 479

EP - 487

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 4

ER -