The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.

P D Canoll; G Barnea; J B Levy; J Sap; M Ehrlich; O Silvennoinen; J Schlessinger; J M Musacchio

The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.

P D Canoll, G Barnea, J B Levy, J Sap, M Ehrlich, O Silvennoinen, J Schlessinger, J M Musacchio

Department of Biomedical Sciences

93 Citations (Scopus)

Abstract

Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is highly expressed in radial glia and other forms of glial cells that play an important role during development. The immunoreactivity localizes to the radial processes of these cells, which act as guides during neuronal migration and axonal elongation. The pattern of RPTP-beta expression changes with the progression of glial cell differentiation. In the adult, high levels of RPTP-beta are seen in regions of the brain where there is continued neurogenesis and neurite outgrowth. The spatial and temporal patterns of RPTP-beta expression suggest that this receptor phosphatase plays a role in morphogenesis and plasticity of the nervous system.

Original language	English
Journal	Brain Research
Volume	75
Issue number	2
Pages (from-to)	293-8
Number of pages	5
ISSN	0006-8993
Publication status	Published - 1993

Cite this

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title = "The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.",

abstract = "Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is highly expressed in radial glia and other forms of glial cells that play an important role during development. The immunoreactivity localizes to the radial processes of these cells, which act as guides during neuronal migration and axonal elongation. The pattern of RPTP-beta expression changes with the progression of glial cell differentiation. In the adult, high levels of RPTP-beta are seen in regions of the brain where there is continued neurogenesis and neurite outgrowth. The spatial and temporal patterns of RPTP-beta expression suggest that this receptor phosphatase plays a role in morphogenesis and plasticity of the nervous system.",

author = "Canoll, {P D} and G Barnea and Levy, {J B} and J Sap and M Ehrlich and O Silvennoinen and J Schlessinger and Musacchio, {J M}",

note = "Keywords: Animals; Animals, Newborn; Axons; Female; Immunohistochemistry; In Situ Hybridization; Nervous System; Neurites; Neuroglia; Neuronal Plasticity; Pregnancy; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley",

year = "1993",

language = "English",

volume = "75",

pages = "293--8",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.

AU - Canoll, P D

AU - Barnea, G

AU - Levy, J B

AU - Sap, J

AU - Ehrlich, M

AU - Silvennoinen, O

AU - Schlessinger, J

AU - Musacchio, J M

N1 - Keywords: Animals; Animals, Newborn; Axons; Female; Immunohistochemistry; In Situ Hybridization; Nervous System; Neurites; Neuroglia; Neuronal Plasticity; Pregnancy; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley

PY - 1993

Y1 - 1993

N2 - Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is highly expressed in radial glia and other forms of glial cells that play an important role during development. The immunoreactivity localizes to the radial processes of these cells, which act as guides during neuronal migration and axonal elongation. The pattern of RPTP-beta expression changes with the progression of glial cell differentiation. In the adult, high levels of RPTP-beta are seen in regions of the brain where there is continued neurogenesis and neurite outgrowth. The spatial and temporal patterns of RPTP-beta expression suggest that this receptor phosphatase plays a role in morphogenesis and plasticity of the nervous system.

AB - Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is highly expressed in radial glia and other forms of glial cells that play an important role during development. The immunoreactivity localizes to the radial processes of these cells, which act as guides during neuronal migration and axonal elongation. The pattern of RPTP-beta expression changes with the progression of glial cell differentiation. In the adult, high levels of RPTP-beta are seen in regions of the brain where there is continued neurogenesis and neurite outgrowth. The spatial and temporal patterns of RPTP-beta expression suggest that this receptor phosphatase plays a role in morphogenesis and plasticity of the nervous system.

M3 - Journal article

C2 - 8261619

SN - 0006-8993

VL - 75

SP - 293

EP - 298

JO - Brain Research

JF - Brain Research

IS - 2

ER -

The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.

Abstract

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