The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety

Vaida Juozaityte; David Pladevall-Morera; Agnieszka Podolska; Steffen Nørgaard; Brent Neumann; Roger Pocock

doi:10.1073/pnas.1610673114

The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety

Vaida Juozaityte, David Pladevall-Morera, Agnieszka Podolska, Steffen Nørgaard, Brent Neumann, Roger Pocock

14 Citations (Scopus)

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Abstract

Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence in Caenorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence on C. elegans behavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food, C. elegans become sated and enter quiescence. We show that ETS-5 acts to promote roaming and inhibit quiescence by setting the internal "satiety quotient" through fat regulation. Acting from the ASG and BAG sensory neurons, we show that ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to control food-regulated behavioral state switching. Taken together, our results identify a neuronal mechanism for controlling intestinal fat stores and organismal behavioral states in C. elegans, and establish a paradigm for the elucidation of obesity-relevant mechanisms.

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	114
Issue number	9
Pages (from-to)	E1651-E1658
Number of pages	8
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.1610673114
Publication status	Published - 28 Feb 2017

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The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety. / Juozaityte, Vaida ; Pladevall-Morera, David; Podolska, Agnieszka et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 9, 28.02.2017, p. E1651-E1658.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Nørgaard, Steffen

AU - Neumann, Brent

AU - Pocock, Roger

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AB - Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence in Caenorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence on C. elegans behavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food, C. elegans become sated and enter quiescence. We show that ETS-5 acts to promote roaming and inhibit quiescence by setting the internal "satiety quotient" through fat regulation. Acting from the ASG and BAG sensory neurons, we show that ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to control food-regulated behavioral state switching. Taken together, our results identify a neuronal mechanism for controlling intestinal fat stores and organismal behavioral states in C. elegans, and establish a paradigm for the elucidation of obesity-relevant mechanisms.

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The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety

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