The endolymphatic sac, a potential endocrine gland?

TY - JOUR

T1 - The endolymphatic sac, a potential endocrine gland?

AU - Qvortrup, K

AU - Rostgaard, J

AU - Holstein-Rathlou, N H

AU - Bretlau, P

N1 - Keywords: Animals; Endocrine Glands; Endolymphatic Sac; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Natriuretic Agents; Rats; Rats, Wistar

PY - 1999

Y1 - 1999

N2 - A previous investigation indicated that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium re-absorption in the kidneys, which has tentatively been named "saccin". In this study, the ultrastructure of the endolymphatic sac and in particular the chief cells is described, demonstrating that this organ fulfils the morphological criteria of a potential endocrine gland. Accordingly, the chief cells are shown to exhibit all the organelles and characteristics of cells that simultaneously synthesize, secrete, absorb and digest proteins.

AB - A previous investigation indicated that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium re-absorption in the kidneys, which has tentatively been named "saccin". In this study, the ultrastructure of the endolymphatic sac and in particular the chief cells is described, demonstrating that this organ fulfils the morphological criteria of a potential endocrine gland. Accordingly, the chief cells are shown to exhibit all the organelles and characteristics of cells that simultaneously synthesize, secrete, absorb and digest proteins.

M3 - Journal article

C2 - 10320075

SN - 0001-6489

VL - 119

SP - 194

EP - 199

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 2

ER -